A high menaquinone intake reduces the incidence of coronary heart disease.

A high menaquinone intake reduces the incidence of coronary heart disease.

Gast GC, de Roos NM, Sluijs I, Bots ML, Beulens JW, Geleijnse JM, Witteman JC, Grobbee DE, Peeters PH, van der Schouw YT.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands. [email protected]

Vitamin K dependent proteins have been demonstrated to inhibit vascular calcification. Data on the effect of vitamin K intake on coronary heart disease (CHD) risk, however, are scarce. To examine the relationship between dietary vitamins K(1) and K(2) intake, and its subtypes, and the incidence of CHD.

We used data from the Prospect-EPIC cohort consisting of 16,057 women, enrolled between 1993 and 1997 and aged 49-70 years, who were free of cardiovascular diseases at baseline. Intake of vitamin K and other nutrients was estimated with a food frequency questionnaire. Multivariate Cox proportional hazards models were used to analyse the data. After a mean+/-SD follow-up of 8.1+/-1.6 years, we identified 480 incident cases of CHD. Mean vitamin K(1) intake was 211.7+/-100.3 microg/d and vitamin K(2) intake was 29.1+/-12.8 microg/d. After adjustment for traditional risk factors and dietary factors, we observed an inverse association between vitamin K(2) and risk of CHD with a Hazard Ratio (HR) of 0.91 [95% CI 0.85-1.00] per 10 microg/d vitamin K(2) intake. This association was mainly due to vitamin K(2) subtypes MK-7, MK-8 and MK-9. Vitamin K(1) intake was not significantly related to CHD.

A high intake of menoquinones, especially MK-7, MK-8 and MK-9, could protect against CHD. However, more research is necessary to define optimal intake levels of vitamin K intake for the prevention of CHD.


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kudzu bob says July 17, 2012

When I attempted to look at your other blog–which has been unusually quiet of late–just now, I got a message saying that it is open to invited readers only.

This very much like what happened with OneSTDV’s blog.

Have you decided to quit blogging, or is there some problem with Blogspot?

In either case, best of luck.

Mangan says July 17, 2012

Thanks, guys. No problem with blogspot; I won’t be blogging there any longer.

    LDiracDelta says July 18, 2012

    Will you be maintaining a canonical blog/feed like Steve Sailer so we can find your posts?

    Mangan says July 18, 2012

    I hope to be blogging elsewhere soon, in such a way that former readers can find me and will know who it is that’s writing. Stay tuned…

    Anonymous says July 19, 2012

    Will you be keeping the Breviary at Blogger or moving it too? Though I don’t comment here much, I will say that I often find it just as or sometimes more interesting than the main blog.

    Thanks for all of your work educating us!

    HiggsBoson says July 19, 2012

    “I hope to be blogging elsewhere soon”

    Good to hear because your blog was important to me.

Mangan says July 19, 2012

Thanks Anon and Higgs. I don’t see any reason to remove this blog, and I’m glad you get some value from it. I’ve been a bit busy of late, but I’ll soon be blogging here as usual I think.

    Anonymous says July 21, 2012

    I would love to read your “implications of dopamine downregulation” post. Could you perhaps e-mail it to shecantsayno AT hush.com?

eah says July 20, 2012

I hope you will find a way to preserve or archive the old blog.

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