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Great summary.
Presumably, it wouldn’t be too difficult or expensive to incorporate all of these into a daily regimen of fasting/exercise/supplementation.
Do you personally supplement with resveratrol/curcumin?
ReplySimon, yes I do. I take resveratrol daily, curcumin 3x week. The curcumin is sort of an “extra”, since many of those processes/compounds activate the same things, such as we see above, AMPK. So I’d say there’s overlap, and trying to say definitively what the best combination is, or which supplements best, will involve lots of speculation. Curcumin has somewhat better bioavailability than resveratrol. I also, of course, fast, exercise, take baby aspirin (though not daily) and eat chocolate and drink tea!
ReplyCurrently, the medical establishment only recommends aspirin for those with >1.5% (I think it is) risk of heart attack annually (http://heart.bmj.com/content/85/3/265.short), since it comes with side effects, mainly bleeding. There’s been lots of discussion about changing that recommendation, because the fact that aspirin appears now to have a substantial benefit for cancer risk means that the risk/benefit ratio has changed in its favor. Also, I’ve read that risk of bleeding is actually quite low. But that is the current state of thinking.
ReplyAny thoughts on ibuprofen vs aspirin? My understanding is that ibuprofen has a lesser risk of causing stomach bleeding. But I wonder if it carries the same effects on AMPK.
ReplyApparently it’s the salicylate that aspirin metabolizes into that inhibits AMPK. Ibuprofen is a COX2 inhibitor, as is aspirin, but it looks like ibuprofen doesn’t activate AMPK. From what I’m seeing, medical researchers don’t think too highly of ibuprofen in preventing heart disease either, though I believe it has some anti-platelet and possibly anti-cancer activity. But it looks like for AMPK activation, aspirin beats ibuprofen.
Interestingly, some acne medications and soaps contain salicylic acid, and I’m wondering if the mechanism of action isn’t activation of AMPK, which might stop bacteria from growing, and might do the same to skin cells, preventing pores clogging up.
ReplyI think ibuprofen has shown some promise I’m preventing Parkinson’s
Reply[…] extension by glucose restriction, showing that activation of AMPK is necessary. As we recently saw, activation of AMPK alone, by whatever means, be they chemical compounds, drugs, exercise, or fasting, increases […]
Reply[…] evidence also links the activation of AMPK to lower cancer risk, and exercise, along with fasting, resveratrol, curcumin, and some other things, activates AMPK. Metformin, a diabetes drug which activates AMPK, also reduces cancer risk, showing the importance […]
Replyim 90 years of age and have been taking 650 mg of enteric covered asperins fo the past 28 years. i always believed that aspirin was an anti aging drug. now with the knowledge that 600 mg of aspirin taken daily stimulates the enzyme AMPK. which in turn keeps the cells from aging it fortifies my belief. i still work everyday i do not look or act 90 years i also read a study that if the aspirins desolve in the intestines it helps produce AMPK in the brain.
ReplyI’m 30 years of age and take 500mg of aspirin every day.
Of course, that’s because I’m hungover every day, but now I know I’m going to live forever.
Thank you Mr. Silk.
ReplyKidding–I stopped abusing alcohol at 28!
Keep up the great work Mr. Mangan, and I hope Mr. Silk lives to 120.
I own your supplement book and will be purchasing your new life extension book. I also plan on gifting a copy to my 65 year old father. He is on a LCHF diet and looks 50, but he doesn’t supplement (other than vitamin D) or pursue any other anti-aging strategies.
It would be wonderful if he could somehow still be alive when I am 65–at which time he’d be 100 years old!
ReplyI use a lot of turmeric (curcumin) in cooking? how much are you taking as a supplement?
ReplyI use 500 mg curcumin several times a week, but note that curcumin and turmeric are not the same. Curcumin is a constituent of turmeric at about 2 to 8 % of total weight. My supplement is 95% curcuminoids.
Reply[…] They are all related and linked through cellular sensors and pathways, most notably through the cellular energy sensor AMPK, which regulates aging. Improving the parameters of one of these factors also improves the others. Lowering oxidative […]
Reply[…] are known life extenders, and it’s usually thought that most of their benefit comes from activating the cellular energy sensor AMPK, making them essentially calorie-restriction mimetics. It turns out that many of these also bind to […]
Reply[…] most importantly for its mechanism of action, it activates AMPK. See the following illustration, and note the presence of metformin at the […]
Reply[…] of Nrf2. Nrf2 is a gene transcription factor that causes the up-regulation of genes that produce […]
Reply[…] Aging is controlled in part by AMPK, which is a cellular nutrient/energy sensor. Many of the same things that cause hormesis activate […]
Reply[…] induces and/or boosts autophagy, by upregulating AMPK and downregulating […]
Reply[…] to muscle shows that CR in middle-aged rats preserves muscle mass. It does this by activating AMPK, a cellular signaling mechanism at the center of a network that controls the aging process and which is crucially involved in lifespan extension. Preserving muscle mass and counteracting […]
Reply[…] glutathione — which is its main mechanism of action — and by doing so inhibited mTOR (mammalian target of rapamycin), the chief driver of growth and a promter of […]
Reply[…] induces and/or boosts autophagy, by upregulating AMPK and downregulating […]
Reply[…] compounds are listed on the site, and we’ve discussed many of them here as well, but we’ll just look at a few of them here that have been tested in a couple of recent […]
Reply[…] aspirin use prevents cancer, and does so by a number of mechanisms, such as iron chelation and AMPK activation. For this brief report, I want to note also that aspirin use prevents lung […]
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