Aromatase inhibitors, doctors, & me

best aromatase inhibitor for men

Anastrozole (trade name Arimidex), best aromatase inhibitor for men?

Testosterone Replacement Therapy

Here’s the story of what I think is the best aromatase inhibitor and my experience with it.

Awhile back, I read a post at Danger and Play on testosterone replacement therapy (TRT). While I wasn’t terribly interested in injecting myself with testosterone once a week or even more often, the take-home message I got from that post is this: why would you let anyone else’s opinion on TRT influence your course of action? Sure, if there are health risks to TRT and someone knows better than me, I’m always ready to listen, but most of the objections to TRT that I’ve seen are moralistic, to the effect that you shouldn’t take T because it isn’t “natural” or something like that. Apparently you should just be satisfied with getting older, losing your muscle or your sex drive, becoming weak, in general just fading away, all because someone somewhere doesn’t like the idea of boosting testosterone. But I decided that that was all hogwash.

The reasons that I wasn’t terribly interested in TRT as far as injections went were two. One, while I’m nearly 60 years old, my T levels were not so bad, having been measured at 575 a couple years back. I can probably credit that to a decent diet (low-carb paleo) and my weightlifting habit. The second reason is the expense: unless one is willing to go the illegal or semi-legal routes, you’ve got to pay for a doctor (unless insurance covers that, more on this below), as well as the T itself. The doctor is by far the biggest expense; if you’re paying cash out of pocket, and going to a doc you’ve never seen before, then you’re talking hundreds of dollars just to get going, besides all the hassle of appointments and so on.

Nevertheless, I thought boosting my T levels might be a good thing to do.

I already had a doctor of longstanding who helped me with chronic fatigue syndrome. He’s a cash only doctor, doesn’t take insurance, but I saw and paid him willingly for years because the other doctors I’d seen for my fatigue were not much use. Even though I’ve recovered from my chronic fatigue, I still occasionally see him, and so I emailed him and asked whether, at a T level of 575, he considered me a candidate for TRT.

Most doctors would not, I think, even consider TRT for a man with a T level that high. Testosterone is listed as a Schedule 3 drug, which means it’s considered to have a potential for abuse, and is therefore tightly controlled. Doctors can come in for extra scrutiny when they prescribe too many controlled drugs, and I think this accounts for the reluctance of many doctors to do so.

An aromatase inhibitor

My own doctor shot back with a suggestion: an aromatase inhibitor. Aromatase inhibitors work to boost T by decreasing the production of estrogens, especially estradiol, the most potent estrogen. Since estradiol feeds back on natural T production, inhibiting it, lowering estradiol levels results in an increase in T. My estradiol level at the last reading had been 70, higher than the upper limit of normal for men. Why that was I don’t know, but estradiol levels increase with age in men, so maybe that was all there was to it.

So my doctor prescribed me anastrozole, the most commonly used aromatase inhibitor. Anastrozole, also known by the trade name of Arimidex, is generic and cheap: I pay about twelve dollars for a three month supply. The dosage is one-half milligram twice a week, which is quite low. Estradiol is necessary even in men, with things like bone composition depending on it, so you don’t want to drive it too low or abolish it altogether.

I noticed a difference shortly after starting to take it. For one thing, my exercise recovery appears a lot better. I used to need a solid three days off between weight sessions in order to recover fully; now I need only two. I haven’t gained any weight, but I’d say my body composition is better: a bit leaner, a bit more muscle. (I can’t seem to gain weight to save my life at this point.) And, yes, my sex drive increased noticeably.

Last time my T level was measured, it had increased to 700, a modest increase of about 20%. In some studies, using higher doses of anastrozole and in low T men, T levels have increased as much as 50%, and free T levels even more. Probably my modest but noticeable results came about because I use a low dose and wasn’t low T to begin with.

However, my estradiol level decreased to 40, well within the normal range of a young man. This may also account for what I consider a successful result of the treatment.

Doctors and the best aromatase inhibitor

Reinforcing what I wrote above about doctors, I recently went to see a new doc, insurance-paid, for the first time, and told him I was taking an aromatase inhibitor, which I coyly said was to lower my estradiol levels. He said that he’d never heard of it being used for that, and told me that I needed to see an endocrinologist, as he wasn’t going to prescribe it for me.

Hell with that, I thought. I went back to my old, cash-only doc, who had no problem renewing my prescription for anastrozole. I intend to keep taking it for some time to come.

Who should consider taking an aromatase inhibitor?

There’s been a generational, secular decline in testosterone levels, which may be caused by environmental pollutants, endocrine disruptors, or obesity, or all of them together. Many men, even young men, have low T levels, and if this is caused by estrogens in the environment, an aromatase inhibitor might be just the thing. If you can’t seem to get rid of that belly fat, or your exercise recovery doesn’t seem right, this might be something to consider.

As for older men, an aromatase inhibitor could help them too. The possible downsides seem low, anastrozole is cheap, and it may not be difficult to find a doc willing to prescribe it.

PS: For more on raing T and building muscle, see my book, Muscle Up.

PPS: Check out my Supplements Buying Guide for Men.

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39 comments
Simon says March 3, 2015

That’s an amazing natural T level for someone your age, props. Absolutely no reason for you to consider TRT. By way of comparison, before I started on TRT, my own was around 220 at the age of 31.

I use arimidex as part of my TRT regime, and as you rightly point out, there is a “sweet spot” – take too much and crash your E2 levels and you’ll lose sex drive, and become lethargic, amongst other more serious potential side effects.

The jabs really aren’t that bad once you get used to it – you can use an insulin needle and do sub-cutaneous injections. They’re totally painless, and take only a few minutes from filling the needle to being done.

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    P. D. Mangan says March 3, 2015

    Thanks for the interesting comment, Simon. Did you discover any reason why your T level was so low at such a young age? And do you know your current T level?

    Reply
Jerry says March 3, 2015

I began taking TRT 5 years ago when my total was above 540. I had all the symptoms of low t. Once I got dialed in I felt great. Estrogen and Free test along with Shbg are more important numbers than total t. Symptoms are the key. I normally run at much higher levels but everyone is different. At 55 and 8% body fat with lots of lean muscle is where I want to live

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Jeff says March 3, 2015

I don’t have time to look things up, but just a general word of caution operating from memory. Anti-e’s are not necessarily safe. No one knows the long-term implications; these are drugs given to treat women with breast cancer. HCG would be a better way to go if you don’t want to jab yourself with a needle. The needles are not bad, you can actually back-load an insulin needle.

I think the TRT forums at meso-rx have quite a bit on using anti-e’s to boost t. Doesn’t seem to produce the same results. Dr Crisler also put up a post years ago showing various hormonal pathways. You want to hit them all. If you have decent T levels and want a boost try pregnenolone and some DHEA. That combo can do you well. For anti-e’s eat plenty of broccoli which contains DIM.

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Remnant says March 3, 2015

Given your history of vegetarianism (veganism?), chronic fatigue, chronic cardio, etc. as well as simply your age, it is absolutely amazing that you had that level before any treatment. It is also a heartening piece of data about the possibilities of doing amazing things to one’s testosterone levels through diet, exercise and ordinary supplementation alone (that’s assuming your T levels were significantly lower prior to your paleo and weightlifting years).

Thanks for this excellent, informative post.

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LiveFearless says March 4, 2015

This is a refreshing essay since, of course, you’re correct, P.D.

A hit and run accident caused severe brain injury which made countless bodily functions work incorrectly.

I’m thankful that the best doctors on earth didn’t choose to fix me with what boys are calling ‘natural’ means like DHEA, pregnenolone, extra BT-corn-fed steak and whatever other nonsense one can read.

For anyone that chooses to doubt real TRT, HGH, HCG, Arimidex etc, I have some words for you that you must take to heart.

Are you listening? This might save your life.

Your fear of not being ‘natural’ is more likely to lead you to an early, sudden death.

Your estrogen level is most likely sky high while your “free” testosterone is likely extremely low. If either of these are the case, you’ve set yourself up for a scenario of a much earlier and more sudden death.

It is simply evil to have a fear of the most amazing stuff available for a man’s body that’s readily available with a prescription and the best compounding pharmacy in the U S that sources ALL from the U S.

Neurologists that treated me at first were completely clueless about how the kind of brain injury I had causes extreme spikes in estrogen and destroys the production of “free” testosterone.

Because of friends I’ve chosen to make during my career, thankfully, when they found out what had happened, calls were made. I ended up with the best doctors on earth for brain injury, strokes, aneurysm etc.

Had they not stepped in, I would be dead.

I spent most of 2014 in a not well known 24/7 inpatient care program that’s the best in the world at getting people like me back to walking, talking and living life again.

I kept having strokes caused by the effects of the initial injury caused by the hit and run accident.

Why?
Elevated estrogen is known to cause STROKES!
Elevated estrogen causes high blood pressure (mine was always at 110/70 until the hit and run accident).
Elevated estrogen is known to cause heart attacks and cancer.

Most people that had the kind of brain injury that happened to me, they’re still not able to function… or they’re dead.

I’ve always been thankful for each moment because I’ve always loved LIVING life.

Arimidex rids the body of the deluge of estrogen producing chemical toxins that are lining most packaging, plastic bottles, aluminum cans… even the canned fish containers.

Regardless, more than 99% of men doubt the benefits as they stay in their programmed religion against their own masculinity.

They insist on using the word ‘natural’ while they still eat at restaurants and they aren’t in any private food organization that sources real food that’s not poisoned by pesticides or dangerous processes/methods like GMO, BT and the list goes much longer.

Anyone male that mentions the word ‘natural’ in relation to hormones that eats at restaurants and shops at the big chain grocery stores is a walking joke of himself.

In Los Angeles, we do have some restaurants that have real food like one founded by friends of mine, Tender Greens.

Elevated estrogen is NOT natural, and I’m living proof that it is deadly. While it was elevated, strokes kept attacking my brain. You DO NOT want that to happen to you.

I’m not a TV watcher, but I did see the first episode of “House of Cards” Season 3. It brought me to tears because so much of what he experienced due to the blows to his head… that stuff is accurate. Unlike him, I have no desire for alcohol and I’ve refused pain killing meds all the way through this rebuilding.

Again, for the “my testosterone is normal” guy, listening just might save your life.

I mentioned “free” testosterone. It’s not widely mentioned on any forum or blog.

Every time I see a man post his testosterone level that’s within the “normal” range, I’m sickened by the farce of it all.

Your testosterone level can be 1197, but if your “free” testosterone is low, most of that testosterone is not getting delivered to where it must go.

So, “free” testosterone is the delivery system. And that ‘normal’ number guys keep reciting, well it’s like your ongoing reserve. It’s there and it lives to enjoy doing its job of keeping things working in every region of your body.

Imagine that tomorrow, all of a sudden, the water doesn’t flow when you turn on the faucet. You then see on the news that all of the pumps in the whole region malfunctioned at the same time.

The region has five years of water stored in massive reserve tanks just in case… all of that wonderful, perfectly safe, perfectly good water!

Engineers keep posting reports that the water reserves are intact and safe, so everyone should just stay in their homes and not worry about a thing. Everything in the reserve tanks looks normal.

It’s frustrating, however, because there’s all that wonderful water, but without working pumps, that water isn’t going to go through any pipes. No washing the clothes, no bathing the people, no cleaning any hands. It’s a mess!

With no water, other things are going wrong… people are becoming extremely ill. Everyone wants to tap into the five year reserve tanks to distribute the perfectly good water exists. But, without those pumps working, there’s no easy way to get that water up to each house, business etc.

The government of the region wants all of the pumps to all simultaneously, naturally, fix themselves. After all, the machines are supposed to last another 60 years.

So they send men in to clean the pumps and paint them with a much higher quality paint. No matter what they do, nothing is causing the pumps to begin working.

That’s what all of this talk about your testosterone level being ‘normal’ is like. There’s plenty of testosterone, but the “free” testosterone is deficient.

The “free” testosterone is the transport system.

The “free” testosterone is like an army of Fedex delivery professionals that always get the testosterone where it needs to be and when it needs to be there.

Otherwise, it’s just sitting there, looking normal, but not doing its job where it is needed.

If your doctor doesn’t test your estrogen level…
If your doctor doesn’t separate out your “free testosterone” level…
If your doctor doesn’t order regular DEXA scans on you…

You need to get out of that office!

Human Growth Hormone helps correct your “free” testosterone. Again, if your T level is in the “normal range” this does not give you the real picture.

Here’s a secret: The BEST doctors, in general,
a. Do not take new patients
b. Have chosen not be be in network with ANY insurer
c. Yes, I have the best PPO health insurance plan, but the best doctors take cash up front, and they also have the freedom to spend the time with me while doing what they must do to keep me alive and to completely rebuild my mind, body and life.

@Jeff “Dr. Crisler” advocates for creams and gels rather than injections. My close friend Mike at Danger and Play can elaborate on going the creams and gels way: http://www.dangerandplay.com/2014/08/11/red-skin-syndrome/

This post by Mike Cernovich gives an EXACT plan: http://www.dangerandplay.com/2014/05/02/went-testosterone-replacement-therapy/
Pay close attention to the ‘half-life’ part, and notice that it’s all injections.
I’m happy to share the names of the best and most reasonable doctors I’ve found to refer my close friends to.

What is the reason they give Arimidex to women with breast cancer?

Elevated estrogen levels create a near perfect environment for much more rapid cancer growth. It’s wise logic to dump that excess estrogen out.

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Clyde Packer says March 4, 2015

I like eating paleo and lifting but i like beer more.

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Andy Granda says March 4, 2015

I have also heard of some people using low dosage Clomid as a way to boost testosterone. There have also been several studies done to back this up. Do you have any experience with Clomid?

http://www.ncbi.nlm.nih.gov/pubmed/19694928

http://www.ncbi.nlm.nih.gov/pubmed/22951175

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    P. D. Mangan says March 4, 2015

    Andy, no experience with Clomid. looks like it works in a similar fashion, inhibiting estrogen receptors and thus lifting negative feedback from testosterone production. Based on admittedly scanty data, it looks like anastrozole treatment might be a lot cheaper.

    Reply
      LiveFearless says March 4, 2015

      Clomid is prescribed by a wimpy male urologist, he’s married with kids. He’s threatened at the thought of making you a more confident, easy going Man that causes beautiful women to inexplicably desire you. He knows that Clomid will make you cry often for no apparent reason and guarantee the end to your ability to attract your partner or someone new. As further effort to protect his self image, he will prescribe testosterone cream or gel instead of injectable since injectable Testosterone will make you the confident man that Dr. Wimp Man AFC is afraid to be. Clomid is prescribed by some doctors to men cycling off of Testosterone, but why would any man cycle of of the stuff that makes him confident, stable, focused, creative, boldness, ability to make peace, it makes sex better (list is endless), makes his penis larger and so on? Let me remind you, when I was dealing with paralysis, etc, testosterone was one of the first solutions the best doctors in the world used to rebuild my brain and body. Arimidex is a miracle for a man! Take Clomid if you want to feel horrible about yourself. But you should read “The Rational Male” by Rollo Tomassi instead. If you’re frustrated with the belly fat, get P.D. Mangan’s latest book. I respect P.D. but he should charge $2,999 for that book instead of $2,99 … It’s that powerful! Stop watching TV (though I make a living voicing TV and stuff, but most of my TV work has audiences of women). Use TV time read P.D. Mangan’s latest book.

      Reply
        P. D. Mangan says March 5, 2015

        Great comment, Sam, as I mentioned I don’t know much about Clomid. And thanks for your kind words about my book, very generous of you!

        Reply
          Joel says March 5, 2015

          Any tips for finding the sort of doctor who will help with this?

          Reply
          P. D. Mangan says March 5, 2015

          Joel, my doc is an “integrative medicine” guy, in other words, an M.D. after his name but an alternative type. Might be worth checking out someone similar. Anti-aging docs will prescribe, but that comes at a hefty price.

          Reply
        albert says January 30, 2016

        I need your help please

        Reply
Kindke says March 5, 2015

Just want to add my experience, ive done AI only cycles. With aromasin I noticed a slight anabolic affect but not with letrozole. I think it may be because aromasin improves free T by lowering SHBG.

However I got immediate signs of low E while taking AI’s which made it impractical. sensitivity to aromatase suppression is likely to be genetic. I have no idea what my natural T levels are but I suspect im definitely on the average to low side. Im as beta as they come.

On AI’s the most apparent affect was no libido. I also had slightly shorter temper on aromasin.

AI’s dont come anywhere near being as good as injectable T. That stuff is heavenly. I had none of the psychological changes on AI’s that I had while injecting real T. Infact the psychological changes are probably the best part about T. Your super confident in everything you do. Libido was amazing.

Lastly a word for HCG, I also praise this stuff highly, but its expensive. ( atleast from underground sources )

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    Allan Folz says March 7, 2015

    “…psychological changes are probably the best part about T. Your super confident in everything you do.”

    Haha. I was just thinking how LiveFearless reminded me of Sailer’s take on Andrew Sullivan.

    Reply
LiveFearless says March 5, 2015

@Joel

There’s only one clinic I send my friends to. It does not charge that up front or yearly fee, and they do consults by email and phone. They’re here in Los Angeles, but you don’t have to come here. Further, the pharmacy is here and everything is sourced from the U S. Track back to my web page to contact them.

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    albert says January 30, 2016

    I have health problem i been on suicide watch, for the last 5 yeard i been to doctors was diagnosed with enalarge prostate i was only 20 im 25 now. First year they ruled out any infections utis or stds its been Hell since theyve told me it was all in my head. Funny huh, well i know its not i strain to pee and my body is constantly in pain fever anxiety high blood pressure insonmia i have lost self esteem quality of life. I met this man who had the same problem i did he said he cured his enlarged prostate with an aromatase i inhibitor he said the 90% percent of the time men get enlarge prostates was to much estrogen causing the prostate to enlarge and become feminist. I looked into it called my urologist to see if he could perscribe the aromatase inhibitor and after spending so much money on him cash upfront he said he couldnt that i had ro consult someone who specializes on harmones. It killed me hearing that i need to get back on man u know how much suffering life can be ive lost everything but this last hope that this aromatase i inhibitor can shrink my estrogens levels helping my prostate reduce its enlargement. I need your help brother to put me back on track where can i get this aromatase inhibitor to end this nightmare once and for all.

    Reply
      Dusan says August 15, 2016

      Did aromataze inhibitor help you to cure enlarged prostate?

      Reply
Baron says March 6, 2015

Thanks for this article. I bought your book back in December and have been trying to get my doctor to prescribe this since then. I’m in mid-40s with a T level of 329. Doctor won’t prescribe this, saying it’s an “off-label” use. Also, says T is not low enough to do anything about. Trying to find alternative ways of dealing with this. I definitely have a lot of symptoms of low T.

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Sameer Pawar says April 9, 2015

I m 19..Testosterone levels arw 278ng/dl..estrogen E2 is 116pfgnmol..very high..cortisol 65..this is high.. hypogonadism signs my doc started me on multivitamins..coz I dnt want trt..some fertility increasing medicines..Letrozole 2.5 mg daily..I want my male body back..im very tensed can all this help..and tell me the time to see the accurate results..im hitting the gym now..soo its.s helping…Thanks!!!!!

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    P. D. Mangan says April 10, 2015

    Should work quickly, Sameer. Have you had a test for zinc, or tried supplementing with zinc and magnesium? I would say that your letrozole will be a big help. Good luck, report back and tell us how you’re doing.

    Reply
Podcast with Jay Campbell on his new TRT book - Rogue Health and Fitness says November 10, 2015

[…] the indications for TRT; discusses when you should consider monotherapy with estrogen blockers or aromatase inhibitors; how to find and choose the right doctor; what lab tests should be monitored during the therapy; […]

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big dawg says November 30, 2015

I’m 24 with a test level of 350, which got flagged up a borderline by the doc. Fortunately (or unfortunately) free test on a further test was 3.5 (out of a normal range of 2-12, I believe) so it warranted no futher action.

Am I being gimped by a low-t society? Do you suppose I would see benefits from at least trying armoatase inhibitors?

Thanks

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    P. D. Mangan says November 30, 2015

    It depends on whether you have symptoms, like low libido, depression, or obesity, but if I were in your position, I’d definitely consider aromatase inhibitors.

    Reply
Normal lab values are for fat, sick people - Rogue Health and Fitness says December 7, 2015

[…] but if you do have symptoms, this is important. I have mine tested as part of my treatment with an aromatase inhibitor, and if you want or need a scrip for one, you’ll be getting this […]

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Tuba says February 19, 2016

Lowering your estradiol to increase your T a little seemed like a good idea. I don’t like needles and I am not happy with the idea of taking a lot of T at my age. Some is good, a lot might not be. Prostates can be precarious. Creams get one’s T up to where I am already which is around 600 (which for 65 is not shabby.) So tweaking out another 100 or so from lowering estradoil has appeal to me. Where I have noticed a drop is in recovery time from lifting weights. I used to be able to lift on Monday and left again on Friday. Now I wait a full week… and I am sore longer than I used to be.

Checking your estradiol, however, is not as straight forward as it seems. My GP flatly said no. That’s a female hormone. Period. My GP is female and I find them to be wholly unsympathetic to male medical issues. They will hand out female hormones like candy but male-related stuff is poison to roll ones eyes over and keep tightly regulated. (When normal males are a threat sub-optimal males are the preferred state, age-eunuchs.) Even when we are old we are still beasts…. kind of like being a good Nazi in the female point of view. So I made an appointment with a male urologist who said no. This is someone who makes money off testosterone replacement therapy. Lowering an estrogen metabolite with a $4 presecriptin does not fit into that business plan. Then an integrated MD let me schedule an appointment but then cancelled. Doesn’t do that kind of thing, she said. I have asked to schedule an appointment with a fourth doctor, also an integrated MD — male. Meanwhile I have had my estradiol level tested but the results won’t be back for a few days. Until then I won’t know if anything needs to be lowered or not. Twenty to 30 is the suggested range.

One point to make is that this can all be done without a doctor. The test cost me $71, and a friend who had extra anastrozole gave me some for personal testing purposes (after I know the starting level… he got his from a doctor who no longer takes male patients.) Anastrozole can be bought over the internet but the cost is dollars vs a prescription which is pennies per dose. That is one reason to visit a doctor, pennies per pill vs a couple of dollars. The cost of the doctor pays for itself. Another reason for all their flaws doctors do think medically and can have some insights one might not of though of.

Doctors are a union and a cartel all rolled into one, and if they don’t want to sell you oil or the policy is not to sell you oil they don’t… even when they are wrong. So sometimes you have to create a work around. If my estradiol is up and I lower it then I have a good argument and evidence for a prescription from some doctor. Same goal, just a different route. And if all the Brassicas I eat has my estradiol level low then I’m just out the cost of the test, no big deal and something I can check against years down the road. You gotta beat them at their own game!

And diet is the wild card. I avoid soy products but eat a lot of Brassicas (kale, mustard greens, broccoli and sprouts, brussel sprouts, radishes et cetera.) Those have sulforapanes which can reduce estradiol. We shall see.

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    P. D. Mangan says February 19, 2016

    What a terrible doctor experience. I may have gotten very lucky with mine.

    PS: You can get anastrozole here, decent price: https://teamtlr.com/

    Reply
Tuba says February 22, 2016

Thanks for the link. Your influence on me thus far: I got my iron tested came in at 100. Gave a pint of blood in January, planned to do so in June. That should take iron nearly off the table. I take IP6 at night and I’ve added beans and legumes back into my general paleo diet to reduce iron (and less red meat.) Giving up on doctors for the time being in regards to Estradiol. I got some 1mg anastrozole pills from a friend — test purposes only — and paid for the test. I came in at 33.3 (I’m 65, 173, lift weights, cycle et cetera, 17% body fat, T at 567.) Recommended estradiol levels range from 20 to 30, or 20 to 25, depending on site. I think I can safely reduce my estradiol some. The question is how much anastrozole per week. A milligram in 0.50 mil doses — which would make that easy, a pill a week, half Monday morning, half Thursday night, splitting the week in two.) Or, two milligrams a week, Monday and Thursday. It’s hard to find any info on the efficacy of the drug. I suspect my estradiol was not dramatically out of whack because I eat a lot of the brassica group, avoid soy -related products like poison, and have eliminated plastics in my life (plastic water bottles for example, food cans lined with plastic) to avoid xeno estrogens. I am hoping to use anastrozole to ease me into the T in the 600’s or a tad more. Not really interested in T shots unless a necessity which they are not now.

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Dusan says March 19, 2016

I’ve read that you take Arimidex twice a week. Why don’t you take it daily? What’s possible downsides of taking it everyday?
Thanks

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    P. D. Mangan says March 20, 2016

    Possible downside is too low estradiol.

    Reply
Tuba says April 5, 2016

Update: In February I had my estradiol level measured and it was 33.3 pg/ml. The recommended range is between 20 and 30. So started taking one mg of Arimidex a week, half a milligram Monday morning at 8 and half a milligram Thursday evening at 8, splitting the week in two and also almost exactly splitting its half life (I am not taking testosterone supplements.) I calculated out the successive additive half lives which meant at that dosing schedule I would be at maximum arimidex level and estradiol reduction at six weeks. I had my blood tested at the end of six weeks and my estradiol had dropped to 12.7, some 20.3 points. That is considered too low over the long term increasing risk of osteoporosis and death from clotting et cetera. So I will quit taking Arimixex for this month — three weeks — and then next month start taking one-half a milligram a week with a quarter milligram on Monday mornings and Thursday evenings. As I dropped 20.3 points taking a milligram a week and I liked to recover half that drop so maybe half of the dose I’ve been taking will do that and get me in that 20-30 sweet spot range. I did immediately notice the effects of less estradiol and the more testosterone that creates. Thus I know and like the benefits of reducing the estradiol. Now it just has to be tweaked to hit the sweet spot.

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    Tuba says June 10, 2016

    Follow up eight weeks later. Recap: My starting level of Estradiol was 33.3 (no testosterone therapy, just an active 65- year old guy.) Over 31 is a 100% or so increase in cardiac events. So, I started taking one milligram a week (Arimidex) in one-half milligram doses splitting the week by hours taking half a tab Monday a.m. at 8:30 and half-a-tab Thursday p.m. at 8:30. Six weeks later the estradiol came in a 12.7 more than a 20 point drop This is too low. This is where long-term osteoporosis happens and there is a 300% or so increase in heart attacks etc cetera. So I dropped the dose by half to a quarter milligram twice a week.

    Update: Two months later this came in a 19.9, up 63%. The recommended range is 20-30 but the sweet spot is 23-30. So I should take a little less. One possibility is to drop the doses from eight a month to six, 1/4 tab every five days. If that created a 25% increase in estradiol that would land me around 24/25 the prime range of young men. Or one could just skip every fourth week. One advantage of skipping a week is to give the liver a break. And three weeks on one off might be easier to remember than a tab every five days. But then there is half life to consider which is about half a week. Thoughts?

    Reply
      P. D. Mangan says June 10, 2016

      I’m going to write an update post on my T results, so stay tuned. Where do you get a 12.7 estradiol as too low, and 23 to 30 as the sweet spot? Because I’ve never heard that.

      Reply
Blood Testing Sale - Rogue Health and Fitness says April 6, 2016

[…] Tuba on Aromatase inhibitors, doctors, & me […]

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The 20 Principles of Rogue Health - Rogue Health and Fitness says April 16, 2016

[…] no junk-food diet can help immensely. Beyond that, if more help is necessary, one can consider an aromatase inhibitor or testosterone replacement therapy […]

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How to Raise Testosterone with Arimidex - Rogue Health and Fitness says June 11, 2016

[…] back, I discussed how I decided to raise my testosterone level and how I did it. Basically, my doctor prescribed me anastrozole (trade name Arimidex), an aromatase inhibitor which […]

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Natural Aromatase Inhibitors Testosterone says November 6, 2016

[…] Aromatase inhibitors, doctors, & me – Rogue Health and Fitness – Aromatase inhibitors can boost testosterone levels. The best aromatase inhibitor and my experience with it confirms that it works well. […]

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Natural Testosterone Boosters - Rogue Health and Fitness says December 5, 2016

[…] Anastrozole (Arimidex) is a prescription aromatase inhibitor and testosterone booster which requires a doctor’s prescription; getting a prescription can be inconvenient, especially considering most doctors won’t prescribe it. Also, not every man is a candidate for it, for instance if your estradiol level is in the normal range. However, there are a number of natural aromatase inhibitors and therefore natural testosterone boosters. […]

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