Aspirin increases lifespan

aspirin dramatically cuts prostate cancer risk


In the last post, we discussed a multi-ingredient supplement that increased lifespan in mice. Interestingly (at least to me), one of the ingredients was acetylsalicylic acid, or aspirin. Turns out there’s fairly good reasons for its use.

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice. (The first-named substance is a derivative of ibuprofen.) Title says it all, really.

There was an interesting statement in this article that led to another article with no abstract, so I’ll just quote it here:

Interestingly aspirin use was reported to be associated with increased survival in extreme old age in humans. Aspirin use was associated with increased survival in a 5-year follow-up study of subjects in the Finnish Centenarian Study (Agüero-Torres et al., 2001). The authors concluded that the increased survival was probably not attributable simply to the anti-atherogenic effects of aspirin, because the aspirin group had significantly more cardiovascular disease than the non-aspirin users.

So aspirin is associated with longevity even in humans, especially the oldest ones, centenarians. Aspirin also prolongs the life of C. elegans, the worm used in so many longevity studies.

Finally, there’s a suggestion that lifelong aspirin use might be a means to extend life: Lifelong Aspirin Supplementation as a Means to Extending Life Span.

Those tempted to try this at home should be aware that aspirin use can cause serious, even fatal, bleeding, and in fact that is one of its major side effects. For awhile everyone was popping baby aspirins in order to prevent heart disease, but it turns out that unless one has serious heart disease already, you’re about as likely to have an episode of serious bleeding as to be saved from a heart attack. (This is usually gastrointestinal bleeding.) So doctors are more wary now of who they tell to take aspirin.

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9 comments
end says October 11, 2014

I have heard that aspirin also does double duty as a mild aromatase inhibitor. I’m not sure if you’ve covered this elsewhere in your blog or if it’s supported by research at all.

In your view, what would you consider to be a safe dosage of aspirin for non-analgesic purposes?

Reply
    P. D. Mangan says October 11, 2014

    That’s hard to say. The dose used for anti-platelet action (in heart disease) is usually around 80 mg/d, that is, a baby aspirin, which is 1/4 the size of a regular aspirin tablet. However, even at this dose bleeding can occur. I would like to get my hands on the aspirin for human longevity paper and see what they have to say. I currently take 80 mg of aspirin 2 times a week, which I think will give me some benefit but minimize chances of side effects. (This is not advice of course.)

    In the Finnish centenarian study, however, those taking aspirin were presumably taking high doses (for pain I presume).

    Reply
    P. D. Mangan says October 11, 2014

    BTW, your suggestion about aspirin and aromatase appears correct. See for example: http://cancerres.aacrjournals.org/content/68/7/2507.full.html

    It might be one way that aspirin use prevents cancer.

    Reply
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[…] Aspirin is a known life-extender, and it is no coincidence that it activates AMPK. “At concentrations corresponding to plasma […]

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[…] at 80 mg), the subjects were losing nearly 20 ml of blood a day via intestinal bleeding. See also Aspirin increases lifespan.- […]

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The most potent life extension substance ever - Rogue Health and Fitness says March 21, 2016

[…] already know that aspirin extends lifespan in mammals (mice) and in C. elegans (a worm). So the fact that salicin was involved in the present study is unlikely to be a […]

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Rick849002 says September 7, 2016

You don’t take aspirin every day. You should take it every 10 days because the lifespan of a blood platelet is 10 days. Therefore, blood platelets only need to be effected once during their lifespan. If you don’t believe me, then don’t do it.

Reply
    P. D. Mangan says September 8, 2016

    I’m afraid that’s incorrect on several counts. Platelets turn over constantly, and the action on platelets is not responsible for the lifespan-increasing effect of aspirin. And it’s been shown at it must be taken daily for its anti-cancer effect. Try harder.

    Reply
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[…] is perhaps the most underrated and cheapest life-extension drug currently available. It increases lifespan in mice and prevents heart attacks and cancer. A new study in the International Journal of Cancer reports […]

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