Catching Up with Rogue Health

Dumping Iron, the book

I’ve been busy working on my project, my forthcoming book, Dumping Iron: How You Can Ditch This Secret Killer and Reclaim Your Health, which I’m very excited about. Endorsements from top iron experts have rolled in (read at the link), and, to put it in a nutshell, they love it. I’m currently having the cover designed, and all should be ready soon.

Muscle Up in the gym

The photo above came from a reader who runs a gym. He contacted me for bulk copies of Muscle Up, which he wants to give to new members as a signing bonus. He told me that the book completely validates his way of training. Winning!

Michael Sebastian, who writes at his site Honor and Daring, recently wrote a nice review of Muscle Up. Michael liked it and started lifting (or restarted), and found that he got way better results in terms of body composition than he did with aerobic exercise.

Timo Fischer wrote a great review of Muscle Up a couple months back.

As usual, I’ve come across lots of interesting ideas and papers. I’ve been wanting to install a microblog on this site for the purpose of posting interesting papers that I find, but haven’t managed to get around to it. For now, below are a few interesting ideas that may be useful in improving health.

Aspirin prevents death from prostate cancer

Aspirin Found to Prevent Death from Prostate Cancer, but Not to Protect from Prostate Cancer.(1) Aspirin use, after diagnosis of prostate cancer, decreased death due to cancer by almost 40%. Astounding, if you ask me.

While the researchers found no protective benefit in the prevention of prostate cancer, others have, especially in the large study conducted by Dr. Peter Rothwell.(2)

The effect of aspirin in preventing prostate cancer death is likely due to its ability to prevent metastasis.(3)

Depending on one’s point of view, the comments from the lead researcher who found the effect of aspirin on prostate cancer death are either humorous or tragic:

It is premature to recommend aspirin for prevention of lethal prostate cancer, but men with prostate cancer who may already benefit from aspirin’s cardiovascular effects could have one more reason to consider regular aspirin use.

These studies are certainly thought-provoking, but are best followed by formal clinical trials where we compare use of aspirin to either no treatment or perhaps a placebo.

So instead of widely publicizing these astounding findings, they call for further study and say it’s “premature” to recommend a cheap, OTC, and relatively safe drug to prevent death from cancer. I know that if I had prostate cancer, I’d get on aspirin immediately, regardless of what these worthies say.

So, this is how it works at the highest levels of science and medicine: doctors discover that a cheap OTC treatment dramatically reduces death rates, and they decide not to recommend it.

They’re going to sit on their knowledge rather than give it the widest possible publicity, because… well, because it needs further study. Because they’re too frightened to make a move. Because the head of some medical group might rebuke them… and on and on. 

This episode shows why you need to know more than your doctor about your condition. One of a doctor’s main functions is as a gatekeeper, and you can’t do it yourself. But intelligent people can take over some of a doctor’s diagnostic capability. In fact, if you don’t, you’re leaving yourself at their mercy.

Suppose you got diagnosed with prostate cancer today. You’ve read this article, and you mention to your doctor that aspirin lowers death rates from that disease by 40%. And he says not to take it, it needs further study. What are you going to do?

Aspirin prevents death from Staph infection

Staph infections are a huge source of illness and death, especially if they get into the bloodstream — sepsis.

Aspirin users who had a bloodstream infection with Staphylococcus aureus had an approximately 40% reduced death rate, 12% of users died vs 27% of non-users.(4)

Dialysis patients using aspirin had a 54% reduced rate of even getting a Staph (MRSA) infection, and a reduced risk of it spreading if they did become infected.(5)

It could be that the aspirin users had lower iron levels, which are necessary for the growth and reproduction of this microbe. Or, alternatively, some other mechanism. Whatever the case, Staph doesn’t like aspirin users. Once again this cheap OTC drug is shown to have massive benefits. If you add the risk reduction from infections to that of cancer, aspirin’s risk/benefit ratio becomes even better.

Ketogenic diet as anti-aging diet

I’ve previously written that a low-carbohydrate diet is an anti-aging diet. A paper that was drawn to my attention shows that in children, an anti-epileptic ketogenic diet lowers IGF-1 and slows the rate of growth.(6) As IGF-1 is implicated in aging, this provides further evidence that a low-carbohydrate diet slows aging.

This effect also illustrates the growth-longevity trade-off. Less growth = less aging.

So, does a ketogenic diet result in less muscle growth because of lower IGF-1? No, because muscle growth does not depend on systemic IGF-1.

Curcumin as anti-fungal

Curcumin as a promising antifungal of clinical interest.(7) Curcumin was more potent than a standard anti-fungal drug against several species of fungi.

Between its iron-chelating effect and its anti-fungal effect, curcumin might be of benefit in Alzheimer’s.

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Leave a Comment:

Paloma says March 1, 2016

Hi, P.D.,
Looking forward to your new book!
This morning I went to the nearest hospital and made a blood donation.
I am planning to do so twice a year so I will be helping myself and helping others as well (I am sure that my blood is most valuable as I look after my body so much and have very good health!) 🙂

    P. D. Mangan says March 1, 2016

    Thanks, Paloma! I’m hoping my book will be a game-changer. I’m working on getting the attention of influential people who I hope can give it a wide audience.

Herman Rutner, M.S. says March 1, 2016

After reading Dr Lauffers book, Iron and your Heart, I have advocated in my emails his suggested staged multiple blood transfusions as the best method for reducing iron overload, e.g as ferritin over 200 ng/ml, commonly found in seniors of both sexes. And as an added bonus such blood donations would substantially increase the nation’s transfuse ke blood supply especially of rare blood types. However the Red Cross apparently rejects blood from donors with higher ferritin who most need them. If still the case, it would be a tragic waste of a natural resource especially in catastrophes. But such ferritin overloaded blood can still be processed to get valuable blood components. If this is still Red Cross policy, it seems foolish in light of recent acceptance of blood from HIV donors in apparent remission.

    P. D. Mangan says March 1, 2016

    Herman, what the Red Cross does is reject donors who say that they’re giving it for any reason other than the goodness of their heart. hence if you tell them that your iron is high and want to lower it – rejection. It’s almost like telling them that you’re donating because you want to get tested for HIV – rejection!

    “recent acceptance of blood from HIV donors in apparent remission.” That cannot be true.

      posthasty says March 1, 2016

      Yes, just keep you mouth shut when going to donate. Blood banks are so desperate for blood, particularly regular donors, they’re not going to probe you (aside from the required forms/questions) on your reasons for giving.

      The hemodynamics of blood from hemochromatosis is different. I came across a paper about the difference in platelet “stickiness” and the deformability of RBCs that was independent of serum ferritin levels. That may be their rationale. I’m sure they could get around that problem, but … money.

    Paloma says March 1, 2016

    Hi Herman!
    First rule when talking to a doctor: Always keep something for yourself! They might not be as educated as you are!
    Second rule: Never follow blindly any health advice given by a sanitary. They might not be as educated as you are!
    Totally agree with P.D. in his answer! 😛

Daniel F says March 2, 2016

Great title. Now there is a perfect two phrase, four word mimetic about how to maintain good health: Pumping iron, dumping iron.

    P. D. Mangan says March 3, 2016


rsdDan says March 8, 2016

PD Mangan,

First thanks for the blog and the books, I really appreciate it as someone with aging parents. Its been very helpful.

Quick question, do you have any opinion on cookware? The three most popular types (cast iron, stainless steel with aluminum core, and nonstick) all seem to admit various amounts of metals/materials that may not be positive for our health. (E.g. see this study on nickel contamination in food from stainless steel:

Thanks again for the info!

    P. D. Mangan says March 8, 2016

    Cast iron cookware adds a small amount of iron to food, maybe 1 mg. Otherwise, as far as Teflon or other cookware, I don’t have an opinion, other than don’t microwave anything in plastic.

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