Category Archives for Autophagy

Nobel Prize in Medicine for Autophagy Research

In the news today it was announced that the Japanese scientist Yoshinori Ohsumi won the 2016 Nobel Prize in Physiology or Medicine for his work on the basis of autophagy. Medicine Nobel for research on

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The Garbage Catastrophe of Aging and How to Avoid It

Aging just is damage accumulation Aging is the accumulation of damage and nothing more. As the level of damage rises, cells and the tissue made from them function poorly, and this in turn causes increased

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The Downside of Antioxidants

Free radicals and antioxidants Antioxidants are natural or chemical substances that quench free radicals and therefore, in theory, prevent damage to cells, improve health, and fight aging. The most well-known

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Fasting and the Mechanism of Longevity

Self-cleansing and aging Arguably, the most important driver of aging is the decline in autophagy, the cellular self-cleansing process that rids cells of junk. Aging just is damage, yet at younger ages,

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Protein cycling diet for life extension

Valter Longo is a scientist at the University of Southern California who has done many studies on the anti-aging effects of fasting. He’s studied not just intermittent fasting, but prolonged fasting

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How to Increase Autophagy for Lifespan Extension

The four pathologies of aging Aging can be defined as a breakdown of homeostasis; that is, the organism as it gets older finds it increasingly difficult to regulate itself and to maintain all systems in

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Intermittent Fasting Boosters / Autophagy Enhancers

Calorie restriction and its twin, intermittent fasting, are the most robust life extension interventions known, extending life in lab animals and primates, sometimes by 50% or so. Intermittent fasting

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Autophagy as mechanism of action of psychoactive drugs

I wrote the following and posted it at The Winnower, a website dedicated to open-access science and post-publication peer review. The Winnower will allow science writers and bloggers to cross-post at

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OTC Weight-Loss Aid Hydroxycitrate Promotes Autophagy, May Help Cure Cancer

Hydroxycitrate is an over-the-counter supplement made from the plant Garcinia cambogia, and it has been promoted for weight loss. A review of trials found that it does indeed promote weight loss, but a

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Muscle, fasting, and health: a rant

  Approaches that don’t maximise/preserve your muscle tissue optimally: – Intermittent fasting – Bulletproof Coffee – Carb Backloading Fads. — Nutrition & Training (@AlexFerentinos7)

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Avoid aging with this one weird trick

I’ve written a lot about intermittent fasting and how it is a uniquely healthful practice. One of the main reasons for this is that it enables the process of autophagy to be upregulated. Autophagy,

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Three simple and effective ways to slow aging and increase lifespan

A recent study found that raising levels of the cell signaling molecule AMPK increased lifespan in fruit flies by 30%. (Cell Reports, PDF, press release.) AMPK did this by increasing activity of autophagy,

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Elevated autophagy may help you live longer

Mitochondria hyperfusion and elevated autophagic activity are key mechanisms for cellular bioenergetic preservation in centenarians Mitochondria have been considered for long time as important determinants

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