Category Archives for Hormesis

From My Forthcoming Book: Can You Get Too Many Plant Polyphenols?

In my forthcoming book on supplements, Best Supplements for Men, I give some consideration to the dosage of polyphenols, the beneficial plant chemicals that are associated with much lower death rates.

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Hormesis for Health and Longevity: A Guide

It’s obvious that people we refer to as couch potatoes have worse health than others, although these days the couch potatoes outnumber the others. The reason for their worse health is that they are

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Why Is Obesity Low in Colorado?

Of all the states in the U.S., Colorado has the lowest rate of obesity, at about 20% as of 2015. Mississippi has the highest rate at about 35%. Why is obesity low in Colorado? What could account for the

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The Richest Sources of Dietary Polyphenols Are Not What You Think

Polyphenols are plant compounds that are associated with good health.(1) “Polyphenols are secondary metabolites of plants and are generally involved in defense against ultraviolet radiation or aggression

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Can excessive running kill you?

The concept of hormesis says that small doses of toxins can actually promote health. Chemical compounds such as resveratrol or sulforaphane cause an increase in cellular stress defense mechanisms. Too

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The military school of health and long life

Aging means a progressive deterioration in physiological function and increasing susceptibility to disease and injury. In a nutshell, age means that the body weakens. Therefore, to deter aging, you have

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Hormesis for health

In the last post I wrote about the process of hormesis for health and how it relates to exercise. As noted in that post, hormesis describes a process that has wide application, namely the placing of a

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Fitness does not equal health

Damaging your body through excessive exercise I was inspired to write this on seeing a recent video (which I can’t find at the moment) of a couple of female runners crossing the finish line of the

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Activate the stress response for health and long life

A pesticide extends lifespan in C. elegans In a recent study, researchers screened for a number of chemicals that might extend lifespan in C. elegans, the tiny worm that is often used in aging research.

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Resistance to type 2 diabetes mellitus: a matter of hormesis?

Resistance to type 2 diabetes mellitus: a matter of hormesis? Type 2 diabetes mellitus is characterized by subclinical systemic inflammation and impaired regulation of blood glucose levels. Interestingly,

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Glucose restriction and life extension

Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Schulz TJ, Zarse K, Voigt A, Urban N, Birringer M, Ristow M.SourceDepartment

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New paper by Ristow group on mitochondrial hormesis

Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension. Schmeisser S, Schmeisser K, Weimer S, Groth M, Priebe S, Fazius E, Kuhlow D, Pick D, Einax JW, Guthke R, Platzer M, Zarse

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Cancer mortality and elevation

Cancer mortality, state mean elevations, and other selected predictors. This ecological inquiry compares cancer mortality rates in the U.S. to the predictor of natural background radiation (via land elevation

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Small γ-Ray Doses Prevent Rather than Increase Lung Tumors in Mice.

Small γ-Ray Doses Prevent Rather than Increase Lung Tumors in Mice. We show evidence for low doses of γ rays preventing spontaneous hyperplastic foci and adenomas in the lungs of mice, presumably via

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Evidence supporting radiation hormesis in atomic bomb survivor cancer mortality data

Evidence supporting radiation hormesis in atomic bomb survivor cancer mortality data A recent update on the atomic bomb survivor cancer mortality data has concluded that excess relative risk (ERR) for

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Superoxide and Longevity

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans Author Summary Top An unequivocal demonstration that mitochondria are important for lifespan comes from studies

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Resistance to type 2 diabetes mellitus: a matter of hormesis?

Resistance to type 2 diabetes mellitus: a matter of hormesis? Kolb H, Eizirik DL.Source Immunobiology Research Group, Institute of Molecular Medicine, University of Düsseldorf, D-40001 Düsseldorf, Germany.

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Stress tolerance and lifespan are correlated

Certain manipulations of organisms will reliably extend their lifespans, manipulations such as calorie restriction or the genetic reduction of insulin and IGF-1 (insulin-like growth factor) signalling.

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