Category Archives for Pharmacology

Aspirin, Salicylate, and Cancer

Following are some thoughts on aspirin, salicylate, and cancer. Executive Summary: Aspirin prevents cancer Aspirin has two modes of action, due to acetylation and salicylate Salicylate prevents cancer

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Do Antidepressants and Other Psychiatric Drugs Kill a Half Million People a Year?

Executive Summary Antidepressant use is very high An anti-psychotic drug, Abilify, is the number one best-selling drug (by revenue) in the US People who take psychiatric drugs have much higher death rates Psychiatric

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Organic food is a waste of money and a scam

So-called “organic” food is everywhere now, as the striking success of Whole Foods shows; even major chain supermarkets have organic sections. All the hip people eat organic, and even plenty

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Anxiolytic, Nootropic, and Fat-Burning Theanine

Health-protective effects of green tea A fairly large amount of research has studied green tea and its components, because they “may contribute to a reduction in the risk of cardiovascular disease

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Can long-term antidepressant use worsen depression?

One of the things I learned from a very good book called Anatomy of an Epidemic is that in the old days, when psychiatric drugs were few to nearly non-existent, many patients fared better than they do

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Antidepressants and school shootings

David Healy, author of Pharmageddon, psychiatrist and psychopharmacologist, writes: In the case of violence, the published trials show antidepressants cause it, at a greater rate than alcohol, cannabis,

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Sleeping pills and death

Hypnotics’ association with mortality or cancer: a matched cohort study Daniel F Kripke1, Robert D Langer2, Lawrence E Kline1+ Author Affiliations AbstractObjectives An estimated 6%–10% of US

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Psychiatric drugs and violence

Prescription Drugs Associated with Reports of Violence Towards Others ResultsWe identified 1527 cases of violence disproportionally reported for 31 drugs. Primary suspect drugs included varenicline (an

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Use of n-acetylcysteine in mental illness

N-acetylcysteine as a potentially useful medication to prevent conversion to schizophrenia in at-risk individuals. Abstract Abstract Schizophrenia is a chronic and often severe psychotic disorder. Its

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(R)-alpha-lipoic acid reverses the age-related loss in GSH redox status

(R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis Suh JH, Wang H, Liu RM, Liu J, Hagen TM.Source Department

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Methylene blue enhances memory

Methylene blue is a common and cheap dye used in biology and medicine. Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue. Rojas JC, Bruchey AK, Gonzalez-Lima F.Source Departments

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A Double-Blind Randomized Controlled Trial of N-Acetylcysteine in Cannabis-Dependent Adolescents

A Double-Blind Randomized Controlled Trial of N-Acetylcysteine in Cannabis-Dependent Adolescents. AbstractOBJECTIVE: Preclinical findings suggest that the over-the-counter supplement N-acetylcysteine (NAC),

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DHEA and testosterone enhance effects of weight training

DHEA enhances effects of weight training on muscle mass and strength in elderly women and men The plasma levels of dehydroepiandrosterone (DHEA) and its sulfated form (DHEAS) decline ∼80% between the

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The Effects of Supraphysiologic Doses of Testosterone on Muscle Size and Strength in Normal Men

The Effects of Supraphysiologic Doses of Testosterone on Muscle Size and Strength in Normal Men Bhasin S, Storer TW, Berman N, Callegari C, Clevenger B, Phillips J, Bunnell TJ, Tricker R, Shirazi A, Casaburi

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Can antioxidants treat depression?

Antioxidants as antidepressants: fact or fiction? Scapagnini G, Davinelli S, Drago F, De Lorenzo A, Oriani G. Source Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.

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Oxidative Stress in Mental Illness

A role for glutathione in the pathophysiology of bipolar disorder and schizophrenia? Animal models and relevance to clinical practice. Abstract The tripeptide, glutathione (gamma-glutamylcysteinylglycine)

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N-acetylcysteine for major depressive episodes in bipolar disorder.

N-acetylcysteine for major depressive episodes in bipolar disorder. Abstract OBJECTIVE: In this report, we aimed to evaluate the effect of add-on N-acetylcysteine (NAC) on depressive symptoms and functional

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Lower whole blood glutathione peroxidase (GPX) activity in depression

Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / chronic fatigue syndrome: another pathway that may be associated with coronary artery disease

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