Now available: Stop the Clock: The Optimal Anti-Aging Strategy

Stop the Clock

My new book, Stop the Clock: The Optimal Anti-Aging Strategy, is now available in both paperback and Kindle e-book. Some of the material may be familiar to readers of this site, but I’ve added new stuff that I think makes it well worth reading – though I guess I would say that, right?

The Kindle version is at a greatly reduced price for the next 48 hours.

Paperback here.

Kindle e-book here.

Update: the special is over, but still at a reduced price.

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21 comments
Lurking_Gorilla says June 20, 2015

Excellent! Looking forward to it.

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sabril says June 21, 2015

Nice picture . . . sorry to sound gay, but maybe you should post something without your jacket on so that people can better assess your musculature. Also, if I may ask, how old are you?

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Stephen Werner says June 22, 2015

Well, “soon” happily turned out to be a short wait. Just bought it. Thanks for the discount!

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    P. D. Mangan says June 22, 2015

    My pleasure, Stephen, hope you get some value from it.

    Reply
Steveyyz says June 22, 2015

I just downloaded the Kindle version of your new book and am looking forward to reading it. I really enjoyed and benefitted from your book on supplements. Thank you for your generous pricing!
Regards
Steveyyz

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    P. D. Mangan says June 22, 2015

    Great, Steveyyz. Hope you enjoy it, and glad you got something out of my other book.

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awesome says June 22, 2015

Hey mangan, just bought your new book in the Aus kindle store successfully! Last book that you launched with a discount was $6 in Aus, so we’ll done on getting the discount to work internationally. I’ll buy whatever you launch for a buck, and so should everyone else. It’s a dollar people!

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Pieter says June 23, 2015

I got your previous books and this one also. Thanks for the discount!

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Remnant says June 24, 2015

Dennis,

Congrats on the new book. And you look great; really amazing you’ve achieved in the past few years.

Do you have any thoughts on the impact of high iron levels on health? Anthony Colpo has been highlighting those risks on his blog for some time, and now Richard Nikoley (with collaboration from one of his readers) has posted an epic article on the issue of excess iron.

To say that Nikoley is trying to change the discourse is an understatement. The post is almost a health “theory of everything” in that it really doubles down on the idea that paleo and other grain-focused critiques have been focused on a red herring, and that most of the modern Western health issues (heart-related, obesity-related, diabetes, etc.) can be laid at the door of iron and “enriched” foods. I’m wondering if you have had the time to absorb this, and what you think of it. As a simple health priority, I am convinced of the need for men to monitor their iron levels. But I am also interested in the larger issues Nikoley is drawing attention to, namely whether a good deal of the paleo conventional wisdom may be misplaced.

http://freetheanimal.com/2015/06/enrichment-theory-everything.html

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    P. D. Mangan says June 25, 2015

    Thanks, Remnant. I did see the article earlier after Paul Jaminet tweeted it, and took a look. I’m on board with the idea that excess iron is not a good thing and should be controlled. There are some people out there who even think reseveratrol works by chelating iron. As for a “theory of everything”, I’ll have to read the article more closely, so for now, I’ve no opinion.

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JP says June 30, 2015

At various points in the text you mention:
Resveratrol
Curcumion
Quercetin
ECGC
Lithium
Aspirin
Fish Oil
Nicotinamide
Hydroxycitrate
n-acetylcysteine

Do you really take all of these regularly? Others as well?

(Yes I know this isn’t the supplement book but I haven’t read that one yet.)

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    P. D. Mangan says June 30, 2015

    I do not take quercetin or EGCG, though I do drink tea, from which EGCG is derived, and I’ve been wanting to try quercetin for its killing action on senescent cells. All the rest I do take regularly – not necessarily daily.

    Reply
    Allan Folz says July 11, 2015

    I started taking NAC based on Denis’ blog. I’d endorse it. I think it has given me a reasonably less fatalist disposition.

    I also take Magnesium and Zinc because of things I’ve read here.

    I also swear by fish oil, though more specifically, high-dose EPA.

    Finally, fwiw, vitamin K2 is one that works wonders on the plaque on my teeth and makes me wonder what it’s also doing to my arteries, since heart disease prevention is what got it all its good press.

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Allan Folz says July 11, 2015

Just finished the book earlier this week. It was good. I’d not hesitate it recommend it to any friends or acquaintances that would be unlikely to follow a blog, but would make their way through a shortish book.

There were two very interesting unresolved questions I came away with.

1) Are shorter life-spans a trade-off for the ability to keep growing, or more specifically repair, necessitated by injury recovery? I think of turtles as the quintessential long-lived animal. In fact, a lot of (all?) ocean species are pretty long-lived. Fish don’t fight and they don’t fall down. Sure they get eaten, but it’s swallowed whole. No brutal attack or self-defense. Anyway, getting back to turtles, they more than anything else I can think of have no need to recover from combat.

(Interestingly, turtles are also pretty good at handling starvation. In the book on the Essex whaling ship disaster, there was a passing mention that sailors would keep live turtles on-board weeks and months until such time as they were needed for their meat. The turtles weren’t fed. Even worse for the turtle, they were turned and left upside down so they couldn’t escape.)

Of note: people, relative to other terrestrial animals, also don’t fight as much, and do live considerably longer than most other animals. Nasty, brutish, and short, indeed.

2) Given young people have a 8-12 hour natural autophagy rhythm, and as we age our ability for that decreases to where we need 16-20 hours to get the same effect, it all seems a little too tautological: aging is marked by a reduced ability for autophagy, but autophagy is the means by which we slow aging. Well, how did we ever lose the ability to commence good autophagy in 8-12 hours, and thus age? College? 🙂

In any case, I think it speaks to taking resveratrol and curcumin every night, immediately before bed. In fact, unless I’ve missed something, I see no reason to take it any other way. I’ve not gotten around to supplementing those two, but I’m starting to seriously consider it. Thoughts?

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    P. D. Mangan says July 12, 2015

    Thanks, Allan. It seems that one reason humans live so much longer than most other animals is a lack of predation. This gets into r vs K life history; when the environment is dangerous and unstable, animals will tend to age faster and have as many offspring as possible and give them little care. As for trade-off with the ability to repair, one of the insights into aging has to do with the declining force of evolution on older animals. If an animal dies after having many offspring, its genes, which may have contributed in some way to its death (by aging for example) will have already been passed on to its offspring. If it dies when young, its genes will not be passed along. Therefore natural selection is stronger on younger organisms and allows for aging to evolve.

    As for autophagy declining with age, of course if we knew why that happened, we could solve the problem of aging. Whether declining autophagy is a cause or a symptom of aging is a good question, but if it is strengthened, animals live longer.

    I supplement with both resevratrol and curcumin, but I tend to take them in the morning. In the morning, autophagy has been ramped up by overnight fasting, so these supplements might be expected to increase that. However, I don’t have a strong preference and its possible that night time would be better.

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      Allan Folz says July 12, 2015

      RE: longevity — OK… I suppose the argument would be turtles can (do?) stay fertile their whole, long lives, thus rewarding, ie. selecting for, longevity.

      RE: curcumin & resveratrol — I think it comes down to: is autophagy proportional or discrete?

      If proportional, then it might make sense to take the supplements toward the end of a fast to give one’s body a solid “push” into a deep autophagy state it otherwise would not/could not reach on its own.

      If discrete, ie. On/Off, then I think it would make sense to take the supplements at the start of the fast. They will reduce the amount of time it takes one’s body to reach the state of autophagy and thereby maximize the amount of time one is in autophagy.

      If discrete is the case, taking them toward the end of the fast, or even just the latter half, is wasting a good amount of time that you could otherwise be in autophagy. Worse, it may be wasting any of their potential effect if by the time you take them you are already in autophagy anyway. If one does not get “deeper” into autophagy, then there’s no reason to take them after you’re already in autophagy.

      Conversely, if proportional is the case it might be wasting their potential taking them early in the fast. They might be cleared by the liver (or whatever) well before enough glucose & insulin have been metabolized for cells to have begun autophagy, and thus the supplements able to “work their magic.”

      So, any indication on which is more likely to be the case? One thing I’ve figured out to look for is the studies that don’t support taking any particular supplement, how do their procedures differ with the ones that do? I saw this with fish oil. A few of the early studies were using DHA and showed very little benefit. When they switched to using EPA, then they started getting significant results. If you didn’t notice the difference as to which O3 they were using, you might be led to believe supplementing “fish oil” is yet another snake-oil. Or, zinc comes to mind where supplementing zinc to men that were already replete, showed no benefits.

      Also, I may have missed it, but do we know the mechanism whereby these supplements enhance autophagy? That might give a clue.

      Reply
        P. D. Mangan says July 12, 2015

        Autophagy is, as you put it, proportional. For instance, it varies with age in rats around 6-fold (http://www.sciencedirect.com/science/article/pii/S0014480083710233) and can be promoted with antilipolytic drugs like Acipimox, a niacin derivative. (Other things do this too.) So I would be leaning more toward the latter, that is, taking autophagy boosters well into the fast, since as you say, they might be wasted if taken too early with lots of glucose and insulin around.

        These supplements enhance autophagy generally by activating AMPK. Some others like lithium have a different mechanism.

        This is a very good resource on autophagy. http://www.tandfonline.com/doi/pdf/10.4161/auto.1.3.2017

        Reply
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