Creatine prevents fat accumulation in liver

Creatine Supplementation Prevents the Accumulation of Fat in the Livers of Rats Fed a High-Fat Diet

The aim of the present study was to examine the effects of creatine supplementation on liver fat accumulation induced by a high-fat diet in rats. Rats were fed 1 of 3 different diets for 3 wk: a control liquid diet (C), a high-fat liquid diet (HF), or a high-fat liquid diet supplemented with creatine (HFC). The C and HF diets contained, respectively, 35 and 71% of energy derived from fat. Creatine supplementation involved the addition of 1% (wt:v) of creatine monohydrate to the liquid diet. The HF diet increased total liver fat concentration, liver TG, and liver TBARS and decreased the hepatic S-adenosylmethionine (SAM) concentration. Creatine supplementation normalized all of these perturbations. Creatine supplementation significantly decreased the renal activity of l-arginine:glycine amidinotransferase and plasma guanidinoacetate and prevented the decrease in hepatic SAM concentration in rats fed the HF diet. However, there was no change in either the phosphatidylcholine:phosphatidylethanolamine (PE) ratio or PE N-methyltransferase activity. The HF diet decreased mRNA for PPARα as well as 2 of its targets, carnitine palmitoyltransferase and long-chain acylCoA dehydrogenase. Creatine supplementation normalized these mRNA levels. In conclusion, creatine supplementation prevented the fatty liver induced by feeding rats a HF diet, probably by normalization of the expression of key genes of β-oxidation.

I don’t know whether creatine supplementation would have this effect in a human who is metabolically normal, but since creatine does increase strength and maximal power, it perhaps does so by increasing expression of genes responsible for fat metabolism.

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2 comments
Portlander says April 5, 2014

After reading Peter at Hyperlipid for a number of years I now don’t trust a single rat study. The so-called HF diets are typically mid-F-HC, and always loaded with Crisco or some other industrially refined omega-6. There is no telling what pathology the creatine is helping their livers to recover from, and no way of knowing how likely it is to be in humans with an otherwise healthy diet.

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My Supplement Stack - Rogue Health and Fitness says January 25, 2017

[…] creatine, 3-5 grams. I’ve become somewhat skeptical that creatine will help someone who already eats well. But it’s harmless at worst, and cheap, so… I take it. […]

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