One of the striking facts about men as we age is that we become less manly: we lose the vigor associated with young men, we decline in the hormone, testosterone, that makes us men, and we lose large amounts of the muscle mass that so obviously characterizes male bodies. All of these are associated with increases in body fat, insulin resistance, and a decline in exercise capacity.
To avoid the pitfalls and perils of aging and the diseases that go with it, it is imperative to retain muscle, and along with it the hormones and energy that characterize a fit man, whether he’s old or not.
A paper published a few years ago looked at the effects of testosterone and growth hormone therapy on lean mass and fat mass in men, average age 70: Testosterone and Growth Hormone Improve Body Composition and Muscle Performance in Older Men. (Journal of Clinical Endocrinology and Metabolism.) This study is far more interesting for what it means to be a sedentary old man than for the effects of testosterone and HGH, which are about what you’d expect.
The average muscle loss in men between the ages of 50 and 70 is 30% (from the paper), and from ages 70 to 80, another 20 to 30% of muscle is lost. Add those figures and you’ve got the basis for the fact that most 80-year-old men will have lost 50% of their muscle mass.
The men were randomized to receive transdermal testosterone, 5 or 10 g/d, along with growth hormone, 0, 3, or 5 μg/kg per day, for 16 weeks.
The men in the study had a testosterone level of less than 550 ng/dl, which is interesting and important for the study and for the point I’m going to make, since if you were to see a doctor with a T level much above 300, you’d be lucky to get a scrip. A level of 550 would be considered perfectly normal, even in a much younger man.
The men also had serum IGF-1 levels in the lower tertile of adult male levels.
As I said, the T and HGH supplementation did about what you’d expect. The men getting T at 10 g/d along with growth hormone at 5 μg/kg per day – the highest doses – had the maximum results, gaining lean mass to the tune of nearly 3 kg (6.6 lbs), and losing fat mass of nearly 2.5 kg (5.5 lbs). That was in 4 months time, with no exercise.
Great results, right?
But how much of these men having low T and IGF-1 levels, along with being overweight (BMI 27.4) was more a result of not only being old, but sedentary and eating wrong? I believe that the lifestyle factors of diet and exercise have everything to do with it.
Consider the lean mass gains and fat mass losses of the best performing group. I could take a newbie weightlifter, even one who is 70 years old, and put him on a diet and training program through which he would easily gain 6.6 lbs of muscle and lose 5.5 lbs of fat in 4 months. When I started lifting – admittedly at age 55, not 70 – I put on 30 lbs of muscle in the first 9 months, and 35 in a year. I didn’t have much fat to lose, so I didn’t. And I’m no gifted athlete: I merely trained consistently and correctly, and ate my fill of a low-carb, paleo-style diet, allowing myself occasional cheats, like baked potatoes and alcohol. I did a few weight-gain tricks, like drinking 8-ounce glasses of half-and-half.
Likewise, the men’s exceedingly low IGF-1 levels may have been caused by a poor diet, filled with junky refined carbs and lacking in protein.
How do I know that these men had poor diets? Because almost everyone does.
The point being, these men had let themselves go.
Now, there’s a circular quality to these hormones and the condition these men were in. Obesity will lower your T levels, but lowering T levels can make you obese. Similarly, lowering your muscle mass through aging and no exercise will lower growth hormone, but lowering growth hormone also has adverse effects.
But I have no doubt that, absent debilitating injuries or illness, the 70-year-old men in this study need never have gotten into such shape, and they may very well not have needed the hormonal intervention just to keep themselves from falling apart.
And to be clear, I have nothing against testosterone replacement therapy, and I take a T booster myself. Growth hormone is another ball of wax, and likely is a pro-aging hormone, but far be it from me to say that it should never be used. Just be aware of its possible side effects.
These 70-year-old men were in the beginning stages of frank sarcopenia, which could make their golden years a lot less golden, making them take refuge in a nursing home due to frailty, as well as shortening their lives.
You see old men all around who look like they’ve lost all zest for living: bent over, most of them overweight, no energy, looking forward to another night of crap food and TV.
It need not be that way.