How do omega-3 fatty acids work?

The Scientist features an article that will be absolutely riveting – no joke – for anyone interested in cell physiology and nutrition: Omega-3s: Fishing for a Mechanism
Despite abundant evidence supporting their ability to help prevent and treat cardiovascular disease, the therapeutic effectiveness of fish oil–derived fatty acids remains controversial.

It’s long been thought that one downside to ingesting fish oil is its potential oxidation within the body. Due to the nature of their chemical bonds, these oils are rather easily oxidized, and lipid peroxides, the product of their oxidation, are generally thought to be quite harmful. Now it seems that oxidation may be required for the benefits of omega-3s.

Oxidized DHA stimulates PPAR Gamma, which in turn stimulates mitochondrial biogenesis. This would make them a potent anti-aging therapy.

Read the whole thing.

Link courtesy of Paul Jaminet.

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