Intermittent fasting fights obesity, fatty liver

In mice, anyway:

In a paper published May 17 in , scientists from Salk’s Regulatory Biology Laboratory reported that mice limited to eating during an 8-hour period are healthier than mice that eat freely throughout the day, regardless of the quality and content of their diet. The study sought to determine whether and result from a high-fat diet or from disruption of metabolic cycles.
“It’s a dogma that a high-fat diet leads to obesity and that we should eat frequently when we are awake,” says Satchidananda Panda, an associate professor in the Regulatory Biology Laboratory and senior author of the paper. “Our findings, however, suggest that regular eating times and fasting for a significant number of hours a day might be beneficial to our health.”

Panda’s team fed two sets of mice, which shared the same genes, gender and age, a diet comprising 60 percent of its calories from fat (like eating potato chips and ice-cream for all your meals). One group of mice could eat whenever they wanted, consuming half their food at night (mice are primarily nocturnal) and nibbling throughout the rest of the day. The other group was restricted to eating for only eight hours every night; in essence, fasting for about 16 hours a day. Two control groups ate a standard diet comprising about 13 percent of calories from fat under similar conditions.After 100 days, the mice who ate fatty food frequently throughout the day gained weight and developed high cholesterol, , liver damage and diminished motor control, while the mice in the time-restricted feeding group weighed 28 percent less and showed no despite consuming the same amount of calories from the same . Further, the time-restricted mice outperformed the ad lib eaters and those on a normal diet when given an exercise test.

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3 comments
Steve Parker, M.D. says May 25, 2012

Surely we have similar studies on humans, although I don’t know the results. Unlike S. Panda above, I’m very hesitant to extrapolate mice studies to human beans.

BTW, I wish you had an RSS feed for posts that I could latch onto. I can’t figure it out. (I see the RSS for comments.)

-Steve

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bjdubbs says July 30, 2012

Lost 10 pounds fasting. It works. Solves the “what should I eat” and “I’ll just have a little . . . more” problems. Get lots more sleep too, body doesn’t want to stay awake if I skip dinner, apparently. That has to be more healthy too. So thanks for your blog for introducing me to fasting.

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Mangan says July 31, 2012

You’re welcome; glad it helped. I agree that a big advantage is that it simplifies things.

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