Lifespan increased with complex supplement

It’s known that a number of natural and unnatural (drug) compounds increase lifespan in various laboratory animals, resveratrol, curcumin, and rapamycin for example. What happens if you feed a lab animal, in this case mice, a multi-ingredient supplement designed to increase lifespan? It works.

A Complex Dietary Supplement Extends Longevity of Mice. This study used both transgenic mice, designed to have high levels of growth hormone, and normal mice, and found that transgenic mice had their lifespans extended by 28%, and normal mice by 11%. For humans, that might equate to an extra ten years of life, and more importantly in my opinion, higher quality years.

Another paper with the same lead researcher, C. D. Rollo, found that the same supplement augments learning, brain mass, and mitochondrial activity in aging mice. This paper includes a list of the ingredients of the complex supplement, as follows:

complex supplement
The list is of the usual suspects in anti-aging research, notably including alpha lipoic acid, acetylcarnitine, and green tea extract. Notably missing is resveratrol. Note the inclusion of aspirin (acetylsalicylic acid). Generous doses of omega-3 oils, both cod liver and flax seed, are included.


The dose for a mouse may be translated into a human dose roughly by dividing by a factor of 12. (See here.) Also note that the above list is per 100 mice, so that factor must be taken into account.

Finally, the same supplement dramatically reduced the incidents of tumors and metastasis in tumor-prone mice.

You cannot get this level of supplementation through diet alone. Supplements are required.


Leave a Comment:

zax says October 9, 2014

This is a great post, thanks for drawing attention to this paper (to those of us who don’t read the primary lit). I take about half of the things on that list and I guess I should think about adding a few more.

One of the things that confuses the hell out of me is many of these things are antioxidants and I exercise daily (sometimes 2x daily). In light of other studies that suggest deleterious effects of antioxidants not only on effect of excercise but lifespan (e.g., this here: ), what the hell is a man to do? Either I’m diminishing the effect of my exercise or else I’m going to die young. Which is it?

Can you help reconicle these two issues? How should one time the intake of certain supplements that have an antioxidant effect with focused endurance efforts?

    P. D. Mangan says October 9, 2014

    zax, yes, the antioxidant issue is confusing. The data are far from all in, and there are many conflicting reports, some finding no effect of antioxidants on exercise. One way to look at it I think is that vitamin C, for instance, has multiple functions, and may work as an antioxidant only at high doses.

    One thing that seems to be more certain is that free radicals (or reactive oxygen species, ROS) are not the bane of life as they were once thought to be. They are necessary for cell signaling and, when not in excess, beneficial.

    I personally do not take antioxidants such as C around workouts. If you exercise twice a day, that’s more difficult. If you decide to take C, one way might be in smaller doses (250 to 500 mg?) as away from workouts as possible. Seems to me even a few hours might be enough, especially if it’s after the workout.

    Beyond that, at this point we’re speculating and need more data.

      zax says October 9, 2014

      thanks for your thoughts on that.
      normally I take almost all of my vitamins/supplements around dinner time whereas my quality running happens in the morning or mid-day so thats probably ok or as good as possible.

      lots of things in this complex supplement that I haven’t seen covered here or elsewhere before, I hope you do a write-up of some of these.

Aspirin increases lifespan - Rogue Health and Fitness says October 10, 2014

[…] the last post, we discussed a multi-ingredient supplement that increased lifespan in mice. Interestingly (at […]

DdR says October 17, 2014

Notably missing is also curcumin. This is in my opinion the #1 supplement to control inflammation and cause apoptosis in cancer cells. Has virtually no side-effect profile. Aspirin would be #2, but the internal-bleeding issue is a dangerous side that isn’t worth it to anybody younger than 50.

I supplemented resveratrol for years and noticed no difference.

I think there’s too much conflicting data on fish oil, so I’m staying on the fence and just trying to eat fatty fish a few times a week.

I take NAC only when I have a hangover. Kills it within one hour.

Na-Rala is magic stuff that will cure any blood-sugar issues I’m having. It helps loss weight too, but I’m sceptical of supplementing an antioxidant, so I take it irregularly.

I plan on eventually going on metformin if I can find a willing doc. Will keep blood sugar rock solid and supposedly extends life. Has been used for 50 years, so the long-term side effects (there are none except for increased longevity) are now known. Helps keep weight down too.

Have you ever looked into PQQ?

    P. D. Mangan says October 17, 2014

    PQQ? No. Metformin is a proven longevity extender, but it seems that it could put a dent in muscle hypertrophy, which is why at the moment I’m not that enthusiastic about it.

Cloudswrest says August 2, 2015

I wonder what is the point of supplementing mice with Vit. C, since they make their own endogenous Vit.C. I’m still waiting for some intrepid soul to get some of his liver stem cells extracted, repair the Vit.C. gene with CRISPR tech, and have the stem cells injected back in!

Multi-Supplement Abolishes Brain Cell Loss - Rogue Health and Fitness says June 6, 2016

[…] levels of growth hormone and IGF-1, which promote aging. Previously, Rollo and his team found that this complex, multi-supplement extended their lifespan by 28%, and even extended the lifespan of nor… A more recent study found that this multi-supplement abolishes brain cell loss in these […]

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