It’s known that a number of natural and unnatural (drug) compounds increase lifespan in various laboratory animals, resveratrol, curcumin, and rapamycin for example. What happens if you feed a lab animal, in this case mice, a multi-ingredient supplement designed to increase lifespan? It works.
A Complex Dietary Supplement Extends Longevity of Mice. This study used both transgenic mice, designed to have high levels of growth hormone, and normal mice, and found that transgenic mice had their lifespans extended by 28%, and normal mice by 11%. For humans, that might equate to an extra ten years of life, and more importantly in my opinion, higher quality years.
Another paper with the same lead researcher, C. D. Rollo, found that the same supplement augments learning, brain mass, and mitochondrial activity in aging mice. This paper includes a list of the ingredients of the complex supplement, as follows:
The list is of the usual suspects in anti-aging research, notably including alpha lipoic acid, acetylcarnitine, and green tea extract. Notably missing is resveratrol. Note the inclusion of aspirin (acetylsalicylic acid). Generous doses of omega-3 oils, both cod liver and flax seed, are included.
The dose for a mouse may be translated into a human dose roughly by dividing by a factor of 12. (See here.) Also note that the above list is per 100 mice, so that factor must be taken into account.
Finally, the same supplement dramatically reduced the incidents of tumors and metastasis in tumor-prone mice.
You cannot get this level of supplementation through diet alone. Supplements are required.