A scientist named C. D. Rollo has done extensive work on the ability of a complex supplement to combat aging. He uses a strain of transgenic mice that have high levels of growth hormone and IGF-1, which promote aging. Previously, Rollo and his team found that this complex, multi-supplement extended their lifespan by 28%, and even extended the lifespan of normal, wild-type mice by 11%. A more recent study found that this multi-supplement abolishes brain cell loss in these animals.
The ingredients of the multi-supplement are as follows:
In a just published study, his team used the same transgenic mouse model to study the loss of brain cells, an important malady of aging that leads to dementia, Alzheimer’s disease, and Parkinson’s disease, or in milder cases, cognitive impairment. (1)
These mice experience severe cognitive decline, losing greater than half the cells in the mid-brain region, the equivalent of a human case of Alzheimer’s.
They report that the multi-supplement completely abolishes the loss of brain cells in these mice, reverses cognitive decline, and increases sensory and motor function. Photoreceptor cells in the eyes were also increased.
The researchers comment, “We know of no other treatment with such efficacy, highlighting the potential for prevention or amelioration of human neuropathologies that are similarly associated with oxidative stress, inflammation and cellular dysfunction.” [My emphasis.]
So, what’s going on here?
Excess growth hormone and/or insulin-like growth factor (IGF-1) promote aging, and lead to oxidative stress, mitochondrial dysfunction, inflammation, and insulin resistance. These conditions then lead to the loss of brain cells.
The ingredients in the complex supplement alleviate these conditions and prevent the death of brain cells.
N-acetylcysteine and alpha lipoic acid increase glutathione, the body’s most important internal antioxidant.
Green tea extract promotes autophagy, the cellular self-cleansing process that gets rid of junk molecules that have passed their expiration date.
Acetylsalicylic acid (ASA): this is aspirin, currently one of the most effective anti-aging drugs known.
Omega-3 fatty acids, which are found in fish oil and are very important for health, decrease inflammation.
The list goes on, but the important point is that these ingredients can protect against many of the ravages of aging. It would be difficult if not impossible to obtain the amounts of these substances in the supplement through diet alone.