More muscle, less fat with chocolate and green tea polyphenols

In my latest book, Top Ten Reasons We’re Fat – go ahead and click that link, you know you want it – I discussed the drinking of coffee and tea as possible fat-loss aids. For coffee, most of the link with leanness is association only, that is, leaner people tend to drink more coffee than the overweight. However, with green tea constituents and other polyphenols, an extensive amount of research has shown that they cause fat loss in lab animals, and in humans. Most of the research has focused on EGCG, the major polyphenol constituent of green tea, but it’s also been found that caffeine and theanine have anti-obesity effects as well.

A 2-gram bag of green tea contains about 500 mg of polyphenols, which seems a substantial amount, and if several cups are drunk daily, likely enough to see an effect on fat loss.

A nice review article sums up much of the research. In obesity, accumulation of fat is associated with increased inflammation. The causal arrow of the inflammation and increased fat is somewhat ambiguous. It’s thought that increased inflammation can lead to insulin resistance and other metabolic problems. On the other hand, fat depots are not the inert storage organs that they were thought to be until recently; it’s now known that they actively secrete various inflammatory cytokines, and increase whole-body levels of inflammation. What seems sure is that obesity and inflammation go together, and that decreasing inflammation could be the key to both fat loss and maintaining a lean body weight.

In cell cultures, green tea polyphenols have the effect of “inhibiting preadipocyte differentiation, decreasing adipocyte proliferation, inducing adipocyte apoptosis, suppressing lipogenesis, and promoting lipolysis and fatty acid beta (β)-oxidation”. So fewer fat cells are made and their proliferation inhibited, fat-burning is promoted, and fat cells encouraged to kill themselves (apoptosis).

Both resveratrol and curcumin also have anti-obesity effects, again in cell culture, animals, and humans, although the results don’t appear to be quite as strong as for green tea polyphenols.

Green tea constituents appear to be quite safe: “We conclude that it is safe for healthy individuals to take green tea polyphenol products in amounts equivalent to the EGCG content in 8–16 cups of green tea once a day or in divided doses twice a day for 4 weeks.”

Green tea has the highest concentration of EGCG: “Compared to black tea and oolong tea, green tea contains the highest amount of green tea catechins [15], the major polyphenols in green tea that constitutes about 35% of its total dry weight [14].” However, as someone who drinks mainly black tea, I should point out that black tea contains theaflavins, which are the fermented products of tea polyphenols, and these are thought to be as equally effective as epicatechins.

Chocolate is another source of polyphenols, including epicatechin, of which it has more than green tea. A neat piece of research was just published showing that epicatechin, found in chocolate, can increase grip strength in humans after only 7 days: Effects of (−)-epicatechin on molecular modulators of skeletal muscle growth and differentiation. In mice (part of the same experiment), epicatechin decreased levels of myostatin significantly and substantially, up to 21%, and increased levels of follistatin, an antagonist to myostatin, by up to 56%. Since myostatin inhibits muscle growth and follistatin promotes it, you can see the potential here for muscle hypertrophy.

In the human part of the study, grip strength increased by about 7% in the subjects, average age 62, and the plasma ratio of follistatin/myostatin increased by ~50%.

The human subjects were given 25 mg pure epicatechin twice a day for 7 days. It looks like a healthy heaping teaspoon of cocoa powder may approach this dose. Chocolate also has far more flavonoids than tea or red wine, about two to four times more.

Basically, adding tea and chocolate to your regimen looks like it could very well promote both fat loss and muscle hypertrophy, the latter combined with a suitable weight-training program of course – although the subjects described above did no exercise at all.

Hat tip to Michael Lustgarten.


Leave a Comment:

Josh says February 4, 2015

Interesting. Did you know dark chocolate is also effective as an appetite suppressant?

My friend used to manage a successful candy story. On busy days, there would be no time for a break – so he’d eat a square of dark chocolate to suppress his appetite and he said it worked very well.

How many squares of dark chocolate would you recommend eating per day?

    P. D. Mangan says February 4, 2015

    Let’s see, I used to know that. According to Michael Lustgarten, 1 gram of dark chocolate has about 84 mg of epicatechin. According to another epidemiological study I read recently, the health benefits of chocolate disappeared if the subjects ate more than 2 squares a day, I believe. The study that increased grip strength used only 50 mg/d of epicatechin, which as you can see is less than the amount in 1 square of dark chocolate. I like to drink my chocolate, and I use a heaping teaspoon of cocoa powder to make it, so according to the chart at Lustgarten’s blog, I’m getting a ton. So I think the takeaway here is don’t overdo it.

Joshua says February 9, 2015

“According to another epidemiological study I read recently, the health benefits of chocolate disappeared if the subjects ate more than 2 squares a day, I believe.”

Are you sure they disappeared? Or was it just that no *additional* benefits were seen after the first couple of squares? I’m hoping it’s that, since I enjoy eating maybe 8 squares a day, and have no desire to cut back. 🙂

(Btw, this is a different person than the first “Josh” to comment there. Interesting coincidence.)

    P. D. Mangan says February 9, 2015

    I think I found the study I was referring to: Regular Consumption of Dark Chocolate Is Associated with Low Serum Concentrations of C-Reactive Protein in a Healthy Italian Population. Quote: “The fully adjusted regression model 5 … was used to construct the average dose-response curve. The relationship found was interpreted as a J-shaped curve, because after an initial decrease in the serum CRP concentrations by increasing consumption of dark chocolate, the curve reaches a plateau at higher intake [up to 6.7 g/d, corresponding to a consumption of 1 serving (20 g) of dark chocolate every 3 d] and tends to be reversed at the highest consumption explored.”


    I’m getting a little baffled trying to figure out how much chocolate is in a square of chocolate. The internet has various answers, but in any case you can see that it doesn’t take a lot of chocolate to have an effect. However, this was only for C-reactive protein, an inflammation marker, so I don’t know about other parameters.

    Edit: from looking around a little further, it appears that 1 square of chocolate might be about 10 grams.

Sam says February 18, 2015

I love chocolate. I have a bag of caco nibs. Just ground up coco beans. Very bitter but I love it.

Kaitlin Gardner says March 6, 2015

Hey P.D.

I’m a HUGE chocolate fan! I’ve been really getting into greet tea recently. I actually just wrote a post on the health benefits of it here:

I’d love to know what you think!

Take care,

Weightlifting will extend your lifespan - Rogue Health and Fitness says March 29, 2015

[…] Polyphenols from chocolate and green tea also decrease myostatin considerably. So eat your chocolate and drink your green tea. They’re already proven to be health-promoting, and possibly some of the effect is due to myostatin lowering. […]

Haven M. says July 20, 2015

so I bought some and it knocks me out. Is that normal? I’ll have a pill with lunch and an hour later…very tired.

    P. D. Mangan says July 20, 2015

    That’s interesting, I presume you mean green tea extract. Because someone else recently told me that GTE gave them the best sleep ever. I’ve never heard of that elsewhere and don’t know what possible mechanism would do that.

      Haven M. says July 21, 2015

      I’d assumed it (GTE) would be a stimulant. Weird.

Chocolate prevents death - Rogue Health and Fitness says January 5, 2016

[…] Chocolate lowers levels of myostatin and increases grip strength in humans, as well as causes fat lo… All of these could be expected to improve health and prolong life. Lower myostatin causes longer life in mice. Muscular strength is associated with lower mortality. […]

Coffee, tea, and red wine prevent disease - Rogue Health and Fitness says February 14, 2016

[…] tea, and red wine all have notable health benefits, lowering risk of diabetes, heart disease, and […]

Add Your Reply