Rapamycin extends life- and health span because it slows aging

Rapamycin extends life- and health span because it slows aging

Abstract

Making headlines, a thought-provocative paper by Neff, Ehninger and coworkers claims that rapamycin extends life span but has limited effects on aging. How is that possibly possible? And what is aging if not an increase of the probability of death with age. I discuss that the JCI paper actually shows that rapamycin slows aging and also extends lifespan regardless of its direct anti-cancer activities. Aging is, in part, MTOR-driven: a purposeless continuation of developmental growth. Rapamycin affects the same processes in young and old animals: young animals’ traits and phenotypes, which continuations become hyperfunctional, harmful and lethal later in life.

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Big Animals Die Younger - Rogue Health and Fitness says February 12, 2017

[…] can already get metformin if you find the right doctor, although OTC berberine might be as good. Rapamycin is a promising anti-aging drug that’s being extensively studied, although it has its […]

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