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” it’s the combustion products of tobacco that cause disease. ”
While nicotine itself may be helpful, tobacco, with or without combustion, is potentially harmful, as smokeless tobacco, such as chewing and snuff, also cause cancer and disease. Combustion may even make tobacco less harmful by destroying various toxins (while producing others).
-B
ReplyHere’s a very intriguing set of blog posts suggesting the problem with tobacco is the bacteria:
https://mrheisenbug.wordpress.com/2014/01/30/the-microbial-effects-of-smoking-more-evidence/
Reply… which goes a long way to explaining why chewing tobacco causes cancer in the absence of combustion products.
Reply“7,8-dihydroxyflavone, on the other hand, can be taken orally”
What would be an appropriate dosage – if known?
Strong Supplements Shop (http://www.strongsupplementshop.com/7-8-dihydroxyflavone-by-antaeus-labs) has 20 ng/capsules – 60 capsules for $29.95. If 20 nanograms is an appropriate dosage, not only is this stuff extremely potent, it would be very difficult to handle effectively in a bulk powder. One would need to have an analytical balance capable of such fine measurement, and a draft-free environment to work in.
I have not dealt with this outfit before, and cannot comment on their performance & reliability.. Has anyone else had experience with Strong Supplement Shop?
ReplyStephen, I don’t think 20 ng will do anything – you sure that isn’t a misprint? OK, I just looked at your link and it does indeed look like 20 ng. But even 20 mg isn’t enough. My reading leads me to believe that a human dose would be more like 100 mg. I haven’t dealt with that shop, but I wouldn’t if that’s real.
The study I read (http://www.pnas.org/content/107/6/2687.full) injected mice with either 5 or 20 mg/kg body weight. For a 70 kg man, and accounting for metabolism (divide by 12), that amounts to either ~30 mg or 120 mg. However, the mice were injected; apparently oral bioavailability is much lower. Over at Longecity (http://www.longecity.org/forum/topic/67667-78-dihydroxyflavone/) they’re discussing doses of 30 mg.
ReplyThanks for the info. I thought 20 ng seemed a very small amount relative to the weight of a human body. I think the fact that they went to the trouble of encapsulating it made me curious regarding that amount as a dosage (why bother with capsules unless it’s intended to be swallowed?).
20 ng/capsule * 60 capsules would provide a scant 1.2 mg, and at $30/bottle, that would put it at about $750/dose. Good thing I asked before I was tempted to order.
ReplyGwern has an article about using nicotine as a stimulant. He suggests either nicotine gum or patches rather than tobacco in any form:
ReplyThanks, Joshua. I was honestly reluctant to post it – propriety and all – but a friend convinced me to do it.
ReplyAny concern that nicotine is a powerful insecticide and pesticide? And that its use since WWII has declined because other insecticides were found to be much less harmful to mammals? Whenever I see someone vaping it gives me pause. Would you suck on a can of Raid?
ReplyEverything is poisonous at the right dose. LD50 for caffeine is 127 mg/kg in mice. Nicotine quite non-toxic to humans.(http://www.ecigarette-politics.com/blog/nicotine-high-toxicity-myth-destroyed.html)
You drink coffee? 10 cups a day, maybe less, and you can become psychotic.
ReplyThe main drawback of parabiosis-the ageing young animal. The aging factors are in the General circulation. You want to filter old blood and to remove these substances. There is also a natural filter of the placenta. Pregnancy is the parabiosis. If you connect the vessels coming from the fetus to the pregnant woman (old) female, rejuvenating factors will directly get into the bloodstream of the mother. This “ideal” experiment preclude the aging of the young organism.
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