Resveratrol enhances exercise performance

Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats

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Resveratrol, an antioxidant found in red wine, has beneficial effects on cardiac and skeletal muscle function, similar to the effects of endurance exercise training.
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Combining resveratrol supplementation with exercise training augments the beneficial effects of exercise alone.
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We show that endurance capacity is enhanced in rats whose diet includes resveratrol during a 12 week endurance-training programme.
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Increased endurance was associated with increases in skeletal muscle force, cardiac function, and oxidative metabolism.
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Our results establish that resveratrol is an effective ergogenic aid that enhances exercise performance over exercise alone.
Abstract  Exercise training (ET) improves endurance capacity by increasing both skeletal muscle mitochondrial number and function, as well as contributing to favourable cardiac remodelling. Interestingly, some of the benefits of regular exercise can also be mimicked by the naturally occurring polyphenol, resveratrol (RESV). However, it is not known whether RESV enhances physiological adaptations to ET. To investigate this, male Wistar rats were randomly assigned to a control chow diet or a chow diet that contained RESV (4 g kg−1 of diet) and subsequently subjected to a programme of progressive treadmill running for 12 weeks. ET-induced improvements in exercise performance were enhanced by 21% (P < 0.001) by the addition of RESV to the diet. In soleus muscle, ET + RESV increased both the twitch (1.8-fold; P < 0.05) and tetanic (1.2-fold; P < 0.05) forces generated during isometric contraction, compared to ET alone. In vivo echocardiography demonstrated that ET + RESV also increased the resting left ventricular ejection fraction by 10% (P < 0.05), and reduced left ventricular wall stress compared to ET alone. These functional changes were accompanied by increased cardiac fatty acid oxidation (1.2-fold; P < 0.05) and favourable changes in cardiac gene expression and signal transduction pathways that optimized the utilization of fatty acids in ET + RESV compared to ET alone. Overall, our findings provide evidence that the capacity for fatty acid oxidation is augmented by the addition of RESV to the diet during ET, and that this may contribute to the improved physical performance of rats following ET.

In other studies, exercise has been shown superior to resveratrol in beneficial metabolic effects. But in combination, resveratrol enhanced the effects of exercise.

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5 comments
eah says May 13, 2014

BBC: Red wine health benefits ‘overhyped’

They found no proof that the wine ingredient resveratrol stops heart disease or prolongs life.

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Mangan says May 13, 2014

Thanks, saw that. As I said elsewhere, the purported health benefits of resveratrol never depended on the health status of wine drinkers. There’s simply not enough resveratrol in wine to make much difference.

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pyrrhus says May 19, 2014

What product/dose do you recommend for resveratrol?

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Mangan says May 19, 2014

I don’t take it daily, but a few times a week, about 200 mg. Product is just generic resveratrol powder – cheaper than capsules, take it with a small scoop. Tastes like dirt. From NutraBio.

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Haven M. says June 18, 2015

what of Pterostilbene?

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