Staying Awake Treats Depression

Intermittent fasting has a beneficial effect on both fat loss and aging. This can be for a number of reasons, but perhaps the main one is that it stresses the organism, a form of hormesis. Could this principle apply to other modalities of life besides diet and exercise, such as, for instance, to sleep?

Sleep deprivation therapy

Missing a night’s sleep can provide instant relief from depression, and it works in the majority, perhaps 75%, of those suffering from major depressive disorder, with efficacy on a par or better than antidepressant drugs. There are several important caveats, however, one being that sleep afterwards, even a nap, often brings a relapse of symptoms.

Back when I used to work the occasional graveyard shift, I noticed a strange uplift in mood after the first night’s shift. This would usually dissipate after further shifts, since cumulative lack of sleep began to take hold. But it turns out that sleep deprivation does in fact work in people who are not even depressed, and can cause people with a tendency to mania to become hypomanic or manic.

The origins of the knowledge of the relation between sleep deprivation and depression are usually thought to go back a few decades, but the first ever professor of psychiatry, Johann Christian August Heinroth, wrote about the link as early as 1818. (Heinroth switched from the study of theology to become a doctor “specializing in illnesses that he judged to be related to the soul. This meant that he could be a doctor and also pursue his pastoral passion. Heinroth’s entire concept of mental health and illness was determined by his Christian faith and could be understood as a theopsychiatric symbiosis.”) It appears that Heinroth discovered the power of sleep deprivation using only his acute powers of observation.

Few people are aware of sleep deprivation therapy, despite that it’s been studied extensively.

There are so few financial incentives to promote this therapy: no drugs to sell, no expensive doctor visits.

A number of theories exist as to why it works, and while some facts have been established, there’s no consensus on the mechanism of action. Sleep deprivation induces an increase in levels of brain-derived neurotrophic factor (BDNF), and this correlates with efficacy of the treatment. Other mechanisms are postulated: “Sleep deprivation rapidly upregulates several plasticity-related genes, effects that are noradrenergically mediated; these are the very same genes that are upregulated by chronic antidepressants.” Some of the genes that are upregulated are those that concern circadian rhythms.

There may be ways to get around the relapsing effect of further sleep. Advancing the sleep phase caused over 60% of those who responded initially to sleep deprivation to retain improved mood. Sleep phase advancement means going to bed later; in this case, the patients went to bed at 5:00 P.M. after one night of total sleep deprivation, and then an hour later each day until they were sleeping from 11:00 P.M. to 6:00 A.M.

Another method that has been tried with success is to combine sleep deprivation with light therapy. This usually consists of exposure to bright light (10,000 lux) for an hour in the early morning. “Patients treated with wake therapy in combination with bright light therapy and sleep time stabilization had an augmented and sustained antidepressant response and remission compared to patients treated with exercise, who also had a clinically relevant antidepressant response.” (Bright light therapy alone can be as efficacious as antidepressant drugs. Here’s another therapy that there’s no money in, so most haven’t heard of it.)

Partial sleep deprivation can be as effective as total, and in addition it is easier to do and less stressful. In partial sleep deprivation, the patient wakes up after 4 hours of sleep, at perhaps 2:00 A.M. “Current opinion is that partial sleep deprivation (PSD) in the second half of the night is equally effective as TSD [total sleep deprivation]. There are, however, indications that TSD is superior.” (From Therapeutic use of sleep deprivation in depression.)

In sleep deprivation, the “reported response rates to the treatment are similar to those observed with antidepressant drugs”. Besides this, there are few side effects, and physical illness appears to be the only contraindication. By contrast, antidepressant drugs can cause sexual dysfunction, among other things, not even to mention the black-box suicide warnings now put on the labels of some antidepressant drugs.

So, here we have a no-cost, simple, and effective treatment for depression, and which can even more effectively be combined with bright light therapy and exercise. The patient merely skips one night’s sleep, or in the case of partial sleep deprivation, sleeps only 4 hours, or the first half of the night. After that one’s night’s sleep loss, going to bed later on successive nights may prolong the antidepressant effect. Note that you might come across this therapy labeled as “wake therapy”, which sounds kinder and gentler.

A few unanswered questions I have include whether patients drank coffee when they awoke – I presume they did, and there’s nothing I know that says that this would mitigate any effects, in fact I think it would strengthen them; and whether sleeping less overall, say 7 hours regularly instead of 8, would generally improve mood. A good night’s sleep is extremely important for health, and insomnia is considered a symptom of depression, but maybe too much sleep is no longer a good thing.


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Shawn says December 28, 2014

Nice post. Vitamin D supplements have helped me a lot.

Reach Your Goals This 2015 – A Testosterone-FUELED New Year to Everyone! | About Lifting says December 31, 2014

[…] Mangan’s Article is up about Intermittent sleep fast […]

How To Cure Depression - Thumotic says January 6, 2015

[…] 6:00 AM every day, you can’t be screwing up your life too badly. There is also evidence that a sleep fast can cure depression. If you commit to waking up early, you will almost certainly subject yourself to a few sleep fasts […]

George Ironthumb says January 12, 2015

I actually seemed to have do that recently —by accident
I thought that wasnt healthy..

so here goes:

You see if you are on a graveyad shift, you basically sleep at day and your rythm adjusts to that.
but you will have 2 days a week to cherish when you are able to sleep at night.

I totally hate falling asleep after going home from the last shift of the week, since if I do that I would wake up at night on my first day off

I just slept though a whole day off


So what I did recently is after going home from my last day of work,,I fight the urge of sleeping,,I woul literally wait until the evening bedtime before going to bed(and most of the time I would be up until 1 or 3 am!!)

at first its VERY hard but I think I got used to it and I kinda get a strange feeling of pleasure doing so..

Its nice to know that it was a good thing all along


    P. D. Mangan says January 12, 2015

    Way back when I worked graveyard shifts once in awhile, I noticed it too. I’d come home, sleep about 4 hours, and then wake up with almost a euphoria.

      George Ironthumb says January 12, 2015

      I cannot sleep for just 4 hours,,when I get to sleep after last day of shift,, I would be knoked out till God knows when!!

      So what happens is I wont sleep at all till the night of saturday..

      It felt like hell on the first weeks, man.. but I thinks its worth it..

      Im not sure if bodybuilders in bulking can do that though…

        P. D. Mangan says January 12, 2015

        For me the worst part of graveyards was that I had such a tough time sleeping during the day. I was a runner then but I still did it even on little sleep. Not sure if that’s a healthy practice though, probably not.

Light exposure, obesity, and health - Rogue Health and Fitness says February 15, 2015

[…] Sleep and depression are closely related. On the one hand, insomnia is characteristic of depression, but on the other, one night of total or partial sleep deprivation causes instant relief of depression in most patients. […]

Five Ways to Fight Depression - Rogue Health and Fitness says February 19, 2017

[…] is associated with insomnia, hypersomnia, and disruption of circadian rhythms. Paradoxically, whole or partial sleep deprivation for one night can relieve depression. Advancing the sleep phase (staying up later) can […]

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