truBrain Nootropics: A Review

think-drinksNootropics and the new reality at the workplace

(Full disclosure: this review contains affiliate links.)

Nootropics are substances that can boost cognitive functioning, i.e. they can make you think better, faster, possibly even help you perform better on an IQ test. They’ve been around awhile, but have been getting renewed emphasis and publicity lately, especially in the tech world. Silicon Valley types understand the level of competition out there, and want that extra edge to allow them to out-think and out-work the other guy. A recent article in the San Francisco Chronicle, for example, ‘Nootropics’ gain momentum as ‘smart pills’, outlines just that dynamic, tech workers boosting their thinking power. Tech Crunch says that nootropics aren’t just for tech millionaires, and the Huffington Post asks whether smart drugs will soon sweep the nation.


The other day I came across a company called truBrain, which makes a line of nootropics in both capsule and liquid (drink) form. Their tagline is (re)Designing Focus, and they say that their “UCLA-trained neuroscientists set out to set out to solve the problem that energy drinks do not- genuine focus.” So I asked them to send me some of their products for review, which they did.

The capsules come in rather high-end design small envelopes or packets, the capsules in one packet to be taken in the morning, the capsules in another packet for the early afternoon. Each packet contains five capsules, five identical ones for morning, four of the same plus one different one for the afternoon. truBrain refers to these as the “loading phase”, and state that one should notice more of an effect after taking them for several days. I’m actually unsure why they call it a loading phase, since it appears that you’re supposed to take the same combination every day, even after you’ve “loaded”.

The ingredients

The main reason so many capsules are needed is because the total content of two packets includes four grams of piracetam (and other ingredients, discussed below), and I would guess that each capsule contains only about 500 mg of material.

Piracetam has been used as a cognitive enhancer for several decades. According to, “Healthy people supplementing piracetam do experience little to no cognitive benefit. Though piracetam supplementation in healthy people is understudied, preliminary evidence suggests that piracetam is most effective for older people.” If you’ve read much of this blog, you already know that physical and cognitive decline starts a lot earlier than most people think; for example, muscle loss begins when people are in their 30s, and cognitive decline as well. So while piracetam may not help the average college student get better grades, it seems that it could benefit many of the rest of us who are no longer in our prime. Like me, for example, or maybe a tech worker in his 40s looking for an edge.

The afternoon packet contains one capsule with 200 mg of DHA, an omega-3 fatty acid that’s been linked to cognition. Neuronal cells contain large amounts of DHA (but not EPA, the other main omega-3 fatty acid from fish oil), and there’s some evidence that DHA can improve cognitive function in the elderly, as well as improve mood in depression. DHA needs to be incorporated into cell membranes to have an effect, and that takes time, so this could be one reason truBrain asserts that effects will increase with the time taking their product.

The morning and afternoon packets contain a total of 585 mg acetyl carnitine, which boosts mitochondrial energy production, including in the brain. Flagging energy from poorly functioning mitochondria is a prime correlate of aging, and in the brain, of cognitive decline.

The packets also contain L-tyrosine to the tune of 450 mg. Tyrosine is used to produce the neurotransmitters noradrenaline and dopamine, and according to, has been shown to improve cognition during stress.

The packets contain CDP-choline at 345 mg. CDP-choline can improve memory. Choline, by the way, is a required nutrient, with egg yolks being the best source.

Theanine at 300 mg is included; one would be taking 150 mg in the morning, the same in the afternoon. Theanine effectively reduces anxiety and increases focus, as well as aiding in fat loss. Of all the ingredients listed so far, this is the first that I normally take with some regularity.

Finally, magnesium at 80 mg is included. Although that dose is not negligible, I would not recommend depending on this supplement for magnesium, since magnesium is just too important. Nevertheless, there are solid grounds for magnesium’s role in cognition, through better mitochondrial function and neural connections.

Cognitive effects of truBrain

I’ve been taking these each morning and afternoon for several days now, and I do notice a difference. Whether my IQ has increased I couldn’t say, but I do feel more focused on my work and my head feels clearer. If I were working in the tech industry or something similar, these capsules could give one the needed boost. As it is, they appear to work well for writing, which is what I want. They have no stimulant effect that I can feel, and in fact I feel calmer and less anxious, which may be largely due to the theanine in them. Naturally, I take a fair amount of caffeine when I work, and truBrain seems to accompany that well.

The truBrain drinks offer a quick nootropic dose. The ingredients are somewhat different. For example, the drink they call “Boost” uses oxiracetam and uridine monophosphate, has higher doses of magnesium (200 mg) and theanine (also 200 mg), contains vitamin C at 468 mg, as well as caffeine at 100 mg. Interestingly, the Boost packet contains only 1 fluid ounce of liquid, so you can pour it all into you in one swallow – maybe that facilitates furtive use and then hiding the packet from your coworkers. They’ll never know what hit them.

Boost tastes good enough, a bit like Tang, and in any case with the low volume it doesn’t matter much anyway. One of the other drinks is a caffeine-free version, which may be better for afternoon or evening use – and the Original is similar to Boost, but with 80 mg caffeine instead of 100. If you sign up for a subscription, the drinks come to just under $3 a drink (slightly more for a one-time purchase) which seems reasonable enough given that people spend that much and more for a Starbucks.

After I drank the Boost drink, I felt like I entered a zone of concentration. I had been feeling a bit run down at the time I drank it, and the drink definitely boosted me, although with 100 mg caffeine, about the amount in a small cup of coffee, one would expect that. But the other ingredients must have been doing their job too, as it felt like more than just caffeine. The effect lasted maybe three hours and during that time I was able to get a fair amount of work done.

My overall impression is that both capsules and drinks work well; they improve focus and concentration. More rigorous testing would be needed to determine whether they would boost scores on an IQ test. Whether they work well enough to justify the cost will be an individual decision based on one’s circumstances, but I can see that someone in a high-paying job that requires an edge would happily pay for these. That would seem to apply not just to tech workers but to doctors and lawyers and finance types.

The following are affiliate links.
Free truBrain drinks trial.
Free Core Blend (capsules) trial.


Leave a Comment:

Steve says May 7, 2015

Thanks for this. It would be very interesting to know if the effects are diminished over time as your body adapts to the supplement. I know this happens with caffeine to some extent. Is this the sort of thing one should take regularly, or only during specific times when you want the extra “boost”.

    P. D. Mangan says May 7, 2015

    Steve, I’m afraid I don’t know exactly, but I suspect that there would be little to no diminishing of effects.

Sunny says May 9, 2015

Can one take these nootropics in conjunction with your recommended supplements?

    P. D. Mangan says May 9, 2015

    Sure, I can’t think of any reason why not.

Sam says May 22, 2015

I have a whole bag of nootropics and I’ve taken none of them. Why? I read reports by people who had bad reactions. Memory problems, etc. I’m assuming that if you have quality stuff this won’t be a problem but where and what is quality stuff? Lots of nootropics are from China and God knows what’s in them. Be careful.

JP says May 26, 2015

I am interested in increasing the ability to concentrate. Between the frigging internet and all the other sources of distraction, it is really hard to stay focused. Suggestions?

    P. D. Mangan says May 26, 2015

    I have that problem too. I use the StayFocusd extension on my PC browser to block sites. I block Twitter, a particular source of distraction for me, during daytime hours on weekdays. Theanine, which is a component of truBrain, helps my focus quite a bit too. And there’s always the pharmacological options, Ritalin (which I couldn’t recommend without reservations) and Modafinil.

      JP says May 26, 2015

      I have been toying with the pharmaceutical options but somewhat fear the side effects. (Also there is the shame of telling the doc I am a grown man but lack the self discipline to stay off the web at work.) Would never give them to my kids, that’s for sure. Hadn’t considered Modafinil – but you find it superior to Adderall?

        P. D. Mangan says May 26, 2015

        Adderall is an amphetamine, and Ritalin is little different in its effects, so they both have potential for addiction, and they also increase heart rate and blood pressure. Modafinil doesn’t have those side effects; I would consider the latter as the safer option. Still, it won’t get you off the internet.

          Tom says October 23, 2017

          Adrafinilis a best stimulant (similar to Modafinil) that promotes wakefulness and alertness, but not hyperactivity. Keeps you focused and productive. I have also noticed an improvement in short term memory. Only thing that bothers me is that adrafinil must be processed in the liver.

Sam says May 29, 2015

“…it won’t get you off the internet…”

When I was a kid we stayed outdoors constantly. I can’t imagine having the internet as a child. I love to read and probably would have stayed glued to the internet. People I know have kids and they stay inside playing games all the time.

    P. D. Mangan says May 29, 2015

    I stayed indoors reading books all the time when I was a kid.

Bballer75 says July 4, 2015

Has anyone tried Xenon as a nootropic? They are selling it online now. I guess it’s been used by athletes before for increasing Epo levels and has been banned at some levels of competition but now has been shown to basically increase mental performance as well. Seems like a wonder drug…

    P. D. Mangan says July 4, 2015

    That’s a new one on me. N-acetylcysteine also increases EPO.

      Joe Grip says July 11, 2015

      I think there is a big difference between EPO production in Chinese hamster ovary cells and the use of a product for sports performance in humans. N-acetylcysteine is a well known compound, and no one has ever shown that is can be used as a “doping” product. On the other hand, xenon was apparently being used for over a decade by Russian athletes, and is currently banned as a performance enhancing substance. This doesn’t effect me, as I am not a professional athlete — but given that I am also not a Chinese hamster, I’ll stick to the stuff that works on humans. In terms of xenon improving mental performance, it definitely works for anti-anxiety. I suppose the increased oxygen would also make its way to your brain — which is generally a good thing. It is an odd thing to use — definitely not what one would expect from an inert gas.

        Bballer75 says July 19, 2015

        Hmm, thanks.

TruBrain Review – Nootropic Geek says January 13, 2016

[…] Another reviewer said that the positive results lasted three hours […]

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