Vegetarian genomic study shows not eating meat is not good for you

[This post was written by George Henderson, a New Zealander and researcher at the Auckland University of Technology who is incredibly knowledgeable in physiology and biochemistry, especially as they pertain to metabolism and diet. He is also the founder of the rock band The Puddle, which has recorded numerous albums. His website is The High-Fat Hep C Diet. I’m hoping we’ll have more from him on this site. I’ve added a few notes and clarifications, with permission.]

 

Generally, a study that purported to show that vegan and vegetarian diets are harmful would be welcomed by meat eaters, who get a lot of pseudoscientific criticism from members of those groups, some of it disguised as sober science.

Populations that have eaten a vegetarian diet over several generations have an increased risk of heart disease and cancer, according to a report published in the journal Molecular Biology and Evolution.

The report argues that communities who haven’t consumed meat for generations are more likely to carry genetic mutations that raise the likelihood of inflammatory disease and cancer.

The authors, from Cornell University in the US, believe that the mutation is the result of an adaptation which made it easier for vegetarians to absorb fatty acids from plants. They believe that the mutation, found in the FADS2 gene, causes these fatty acids to be converted into arachidonic acid. [excerpt added by PDM]

But no one was much impressed by the Pune (India) vs. Kansas study. Even Tom Naughton wrote it off as meaning the same thing the head of the NZ vegetarian society said it meant – that omega-6 seed oils just aren’t good for us anyway.

But I thought about this, and, not so fast.

Seed oils high in omega 6 are harmful for the descendants of long lines of vegetarians because such people, because of an adaptation to the virtual absence, from their diets, of DHA and AA (arachidonic acid), the very long-chain polyunsaturated fatty acids found in animal flesh and organ meats, have a more efficient version of the genes involved in synthesizing these fats from alpha-linolenic acid (ALA) and linoleic acid (LA). Too much LA overwhelms these enzymes, which only seem to be loosely regulated, and results in an excess of inflammatory AA products and an inadequacy of very long chain omega 3 fatty acids.

So this adaptation is good for vegetarians eating traditional diets, as in Pune where the traditional fat source would have been ghee, with a little mustard seed oil added. Low in omega 6, balanced in omega 3, enough hearty saturated dairy fat to protect against the diabetogenic effect of a diet high in both starch and sugar.

But think about it – this adaptation isn’t some random lucky fluke. For one gene to dominate over another like this, there needs to be some significant and sustained reproductive advantage.
Reproductive advantage means one or more of these – greater fertility, fewer stillbirths, fewer complications of pregnancy, lower mortality early in life, greater attractiveness to a mate.

The vegetarian PUFA genetic polymorphism flourished because, in the past, people without it, eating vegetarian diets, suffered some combination of infertility, stillbirth, dangerous pregnancy, early mortality, or plain butt-ugliness.

The gene’s incidence at present is 70% in South Asians, 53% in Africans, 29% in East Asians, and 17% in Europeans. That to me indicates a burden of suffering and infertility in South Asians in the past, to produce this result – that’s how evolution works, that’s how Nature selects. If you’re European, the chances are that you do need AA and DHA in your food, unless you want to take your chances with lots of vegetable oil – which seems to me a very second-rate, artificial, and dicey way of getting there.

Note that some vegans do think it’s okay to eat bivalve shellfish, which can’t feel pain (or rather, probably don’t feel more pain that plants do, but who knows what that is). This would supply more than enough DHA and AA. However, PETA takes the hard line on this, like the Buddhist who won’t swat a zika-carrying mosquito.

But then, PETA is Neal Barnard’s baby and he’s a dietary cholesterol zealot, so their ban on shellfish might not be as strictly ethical as they claim. Dr Barnard “advises people to avoid added vegetable oils and other high-fat foods as well as refined sugar and flour”. Well, good for him but it is hard to see where the AA and DHA will come from for the majority of Europeans on this diet.

Maybe veganism is a bit like statinism – enough of the people it’s going to harm will drop out of the trial early for the long-term results to look a bit encouraging. It would be interesting to see if long-term vegans in European populations have in fact self-selected for the FADS2 polymorphism common in Pune.

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4 comments
George Henderson says April 8, 2016

Thanks for reposting this! Co-incidentally I just found some good evidence about polyunsaturates and sperm counts on David Gillespie’s blog.
http://davidgillespie.org/how-vegetable-oils-are-stealing-our-future-part-one/
Egg yolks are a reasonably good source of AA and DHA in vegetarian diets. Our egg laying hens originated in South Asia and reached the West a few centuries BC; there is a cock in the New Testament, but otherwise chickens and eggs are not mentioned in the Bible. When Captain James Cook’s men asked the Tahitians to collect seabird eggs for them, they discovered that the eggs were not being eaten in Tahiti.
http://www.cholesterol-and-health.com/Egg_Yolk.html

Reply
    P. D. Mangan says April 8, 2016

    Great to have you here. George. Great post!

    Reply
Kabir says April 16, 2016

Thanks for an excellent summary of this research George and Dennis. As someone who is ethnically Indian (in fact my ancestors came from very close to where the study was conducted), I am pretty sure my ancestors would have at some point been vegetarian, although my family have been eating meat for at least 3 generations.

I do aim to keep seed oils to an absolute minimum (we only use ghee, olive, coconut and avocado oil at home). However, does this research suggest I might be better off as a vegetarian? Or should I avoid meats that have PUFAs, like salmon and chicken?

Reply
    P. D. Mangan says April 16, 2016

    Hi Kabir, I think the latter, avoidance of foods that have high amounts of omega-6 fats. I don’t think omega-3 needs to be avoided, thus salmon is OK. Chicken does have fairly large amounts on omega-6, but that would be swamped by any use of vegetable oil. Hence, the vegetable (but not olive) oil should go first, then if you feel like you still need improvement, chicken.

    Reply
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