Statins are not the lifesaving drugs that doctors and drug companies make them out to be. They can actually cause heart disease. Effects on lowering mortality are very small, they have never been shown to help women, and do not help in anyone who has not already had a heart attack.
Statins can cause heart disease
A recent study published in Expert Review of Clinical Pharmacology, “Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms”(1), shows how statins can increase coronary artery calcification, a prime risk factor for heart attack.
A newspaper article based on this study quotes the lead author, Harumi Okuyama, saying, “I cannot find any evidence to support people taking statins.”
“We have collected a wealth of information on cholesterol and statins from many published papers and find overwhelming evidence that these drugs accelerate hardening of the arteries and can cause, or worsen, heart failure. I cannot find any evidence to support people taking statins and patients who are on them should stop.”
Among the reasons given for the ability of statins to cause arterial calcification are:
- Statins are toxic to mitochondria. By interfering with the synthesis of CoQ10 and heme A, components of which come from the cholesterol synthesis pathway, statins poison mitochondria and make them less able to generate energy.
- Statin administration and selenium deficiency cause heart failure through a common mechanism. Statins inhibit the synthesis of glutathione peroxidase, leading to increased oxidative stress. They also inhibit superoxide dismutase and catalase, through unknown mechanisms, also leading to oxidative stress.
- Statins inhibit vitamin K2 and accelerate artery calcification. Vitamin K2 is necessary for proper calcium metabolism; inhibiting it leads to calcification – calcium goes where it shouldn’t (arteries) instead of where it should (bones).
- Clinical trials show or suggest that statins lead to more atherosclerotic heart disease and heart failure.
“Progression of Vascular Calcification Is Increased With Statin Use in the Veterans Affairs Diabetes Trial”(2) In ~200 participants who had type 2 diabetes, progression of coronary artery calcification was about double in the more frequent (more compliant) statin users.
The authors of the first cited study conclude their piece as follows:
Pharmacological evidence and clinical trial results support the interpretation that statins stimulate atherogenesis by suppressing vitamin K2 synthesis and thereby enhancing artery calcification. Statins cause heart failure by depleting the myocardium of CoQ10, ‘heme A’ and selenoproteins, thereby impairing mitochondrial ATP production. In summary, statins are not only ineffective in preventing CHD events but instead are capable of increasing CHD and heart failure.
Physicians who are involved in prescribing cholesterol-lowering medications cannot ignore the moral responsibility of ‘informed consent’. Patients must be informed of all statin adverse effects, including the ability to cause CHD and heart failure, onset of diabetes mellitus, carcinogenicity, teratogenicity and central and peripheral nervous disorders besides the well-known rhabdomyolysis and hepatic injury. Most of these adverse effects of statins become apparent after 6 or more years of statin therapy. Chronic administration could ultimately lead to these statin adverse effects as pharmaceutical and biochemical research has now demonstrated.
Here’s a piece of anecdotal evidence (if that makes sense): I know an older man who takes a statin and also has pseudogout, a condition in which calcium is deposited in the joints. It’s painful and debilitating. Is it possible that statins caused his pseudogout? Entirely possible, through the inhibition of vitamin K2 and resultant interference with calcium metabolism.
Statins are ineffective
The “number needed to treat” (NNT) is a medical statistic that shows how many people must be treated with some drug or other intervention in order to prevent one adverse event; in the case of statins, that event would be a heart attack.
In men who had no known heart disease who took statins for 5 years (from the NNT):
- None were helped (life saved)
1 in 104 were helped (preventing heart attack)
1 in 154 were helped (preventing stroke)
- 1 in 50 were harmed (develop diabetes*)
1 in 10 were harmed (muscle damage)
Or to look at the same number another way (from Grant Schofield), 98% saw no benefit, 0.96% benefited from preventing a (non-fatal) heart attack, 2% were harmed by developing diabetes, and 10% were harmed through muscle damage.
To give the reader an idea of a much better NNT, iron reduction in patients with peripheral arterial disease reduced the risk of death or non-fatal heart attack with a NNT of 8, “a very low number rarely encountered in clinical studies.”(3)
Statins are incredibly ineffective.
Statins have been linked to lots of other adverse side effects, such as muscle pain and weakness, memory loss, and diabetes. (See here.)
The Bottom Line
The decision to take a statin or not is yours alone. I hear stories all the time of doctors pressuring their patients to take statins, and one doctor even hinted to me that I ought to be taking them. Unless new evidence comes to light, which seems doubtful, I won’t be taking them, ever.
It’s more than a shame that these drugs are pushed on just about every older person these days. It’s evidence of a corrupt and ignorant medical system.
PS: Check out my Supplements Buying Guide for Men.
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Statins are indeed bad for most people. Doctors prescribe them for three reasons: 1) They lower cholesterol thus fulfilling doctor dogma. 2) The medical guild supports their sale and use so to not prescribe them is to go against guild members and profit practices. (Once you join the club you have to play by the club rules.) And 3) statins reduce some inflammation in some patients so doctors stick with it thinking it is the cholesterol reduction that is doing the trick when that is not so. It’s an ignorant cluster @#$% all around, and trading one set of illnesses for another set. Doctoring is becoming increasingly guided by well-entrenched wrongness. Want to live a long time? Don’t listen to your doctor. A friend of the family said it more than a century ago: Stay away from doctors. They make you sick!
You are indeed in good company on this opinion:
&, if you can find it search for
the documentary Statin Nation
All the best, Nathan
Thanks, Nathan, for those. I’m familiar with Dr. Kendrick, but the first link I’d never seen before, and I ended up buying his low cholesterol book. I may review it. Valuable resource, thanks again.
Thanks for the info, i’m gonna ditch this medication for good(thankfully, i only begun to use it last month). I also use losartan, bezafibrate and pantoprazole are those harmful too?
br, hard to say, I’m less familiar with those. Losartan is for blood pressure and could have side effects; there’s some doubt as to treating blood pressure unless it’s very high. David Brownstein states that blood pressure and lipid guidelines for the elderly are useless: https://blog.drbrownstein.com/blood-pressure-and-lipid-guidelines-for-the-elderly-useless/
Bezafibrate is used to lower cholesterol – but if cholesterol doesn’t cause heart disease…
As for pantoprazole, which is used to treat esophageal reflux from stomach acid, lots of people report that avoiding refined carbohydrates and sugar cured their reflux problem. Myself, I’d stop eating carbs.
Thanks for the reply. I use Bezafibrate to lower triglicerides, but they are still high between 1.000 so it’s not working. Maybe it’s my eating habits which are really not that good, so i’m probably ditching this medicine in the future. I’m 28 and my blood pressure is usually at 140×80 – 120×80 with losartan
Pantoprazole helped me cure my stomach problems, so at least there’s that.
Hi br, Following on from Dennis’s comment I can vouch that dropping refined carbs, sugar and daily coffee (occassional coffee is fine) meant that I could finally stop taking the pantoprazole, which the doctors said I would be on for life! I was very pleased with that as I’m sure you know that by lowering stomach acid it adversely affects the digestion of many vitamins and minerals. Not good.
I ditched Doctors along time ago. I had a heart attack in 2001, diagnosed with type 2 diabetes. I’ve lost 70 lbs. on my own and now take no medications, especially statins. Doctors unfortuneatley are doing more harm than good.
Thanks for commenting, Mr. Morgan, and congratulations on the good work. I’ve come to the conclusion that “checkups” set you up for adverse side effects, and in fact now I wouldn’t go to a doctor unless I was very sick – other than to get my thyroid prescription, which I have to do annually.
People expect most of our social institutions to be poor. We expect government to be incompetent, law to be blind, religion to be stuck in the past, education to miss the point. But there was always the hold out of medicine, folks who have our best interest at heart. But that is no longer true. It is a profession that has become more dogmatic than religion, absolutely convinced of it rightness even when horribly wrong. It has become an impediment to good health.
I eat raw garlic daily for the cardiovascular benefits (https://examine.com/supplements/Garlic/), specifically because my blood pressure runs a bit high (~130/90 before I started garlic supplementation). I also do intermittent fasting (16 hours), and I’m wondering if one clove of raw garlic in the morning would break the fast (4 calories, 1 gram of carbohydrates). Any thoughts?
Thanks for everything you do here!
Hi Matt, no, I wouldn’t worry about a small amount like that. Chomp away!
People interested in more reading on statins may want to include spacedoc.com in their reading
Thanks, Drifter, you’re right, great site on statins.
Best way to get rid of the corruption is to abolish medical licensing.
Rat poison is more beneficial than statins. And just as you can find a person here and there that benefits in the short term from rat poison you can find a person here and there who benefits in the short term from statins. But for most folks long term both are poisons that shorten life. If there ever was a poster child for what is wrong with the medical profession today it is statins. It’s a bad class of drugs which, like many things, has become Doctor Dogma. The inability of the medical profession to rehabilitate itself is sad and irritating… no… now that I ponder it… just irritating.